Leo T M van der Ven
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Explore the profile of Leo T M van der Ven including associated specialties, affiliations and a list of published articles.
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53
Citations
752
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Recent Articles
1.
The zebrafish embryo as a model for chemically-induced steatosis: A case study with three pesticides
Heusinkveld H, Zwart E, de Haan A, Braeuning A, Alarcan J, van der Ven L
Toxicology
. 2024 Aug;
508:153927.
PMID: 39151607
There is an increasing incidence and prevalence of fatty liver disease in the western world, with steatosis as the most prevalent variant. Known causes of steatosis include exposure to food-borne...
2.
Luijten M, Sprong R, Rorije E, van der Ven L
Front Toxicol
. 2022 Oct;
4:933197.
PMID: 36199824
Next generation risk assessment is defined as a knowledge-driven system that allows for cost-efficient assessment of human health risk related to chemical exposure, without animal experimentation. One of the key...
3.
Driessen M, van der Plas-Duivesteijn S, Kienhuis A, van den Brandhof E, Roodbergen M, van de Water B, et al.
Toxicology
. 2022 Jul;
477:153262.
PMID: 35868597
The zebrafish embryo (ZFE) is a promising alternative non-rodent model in toxicology, and initial studies suggested its applicability in detecting hepatic responses related to drug-induced liver injury (DILI). Here, we...
4.
van der Ven L, Van Ommeren P, Zwart E, Gremmer E, Hodemaekers H, Heusinkveld H, et al.
Environ Health Perspect
. 2022 Apr;
130(4):47003.
PMID: 35394809
Background: Humans are exposed to combinations of chemicals. In cumulative risk assessment (CRA), regulatory bodies such as the European Food Safety Authority consider dose addition as a default and sufficiently...
5.
Havermans A, Zwart E, Cremers H, van Schijndel M, Constant R, Meskovic M, et al.
Toxics
. 2021 Oct;
9(10).
PMID: 34678946
Tobacco use is the leading cause of preventable death worldwide and is highly addictive. Nicotine is the main addictive compound in tobacco, but less is known about other components and...
6.
Atzei A, Jense I, Zwart E, Legradi J, Venhuis B, van der Ven L, et al.
Int J Environ Res Public Health
. 2021 Jul;
18(13).
PMID: 34206423
Humans are exposed daily to complex mixtures of chemical substances via food intake, inhalation, and dermal contact. Developmental neurotoxicity is an understudied area and entails one of the most complex...
7.
Menegola E, Veltman C, Battistoni M, Renzo F, Moretto A, Metruccio F, et al.
Toxicology
. 2021 Jun;
458:152843.
PMID: 34186166
Adverse outcome pathway (AOP) is a conceptual framework that links a molecular initiating event (MIE) via intermediate key events (KEs) with adverse effects (adverse outcomes, AO) relevant for risk assessment,...
8.
van der Ven L, Schoonen W, Groot R, den Ouden F, Heusinkveld H, Zwart E, et al.
Toxicol Appl Pharmacol
. 2020 Sep;
407:115249.
PMID: 32979392
The zebrafish embryo toxicity test (ZFET) is a simple medium-throughput test to inform about (sub)acute lethal effects in embryos. Enhanced analysis through morphological and teratological scoring, and through gene expression...
9.
Heusinkveld H, Schoonen W, Hodemaekers H, Nugraha A, Sirks J, Veenma V, et al.
Reprod Toxicol
. 2020 Jun;
96:114-127.
PMID: 32553615
Knowledge on mode-of-action (MOA) is required to understand toxicological effects of compounds, notably in the context of risk assessment of mixtures. Such information is generally scarce, and often complicated by...
10.
Luijten M, Rorije E, Sprong R, van der Ven L
Chem Res Toxicol
. 2020 Mar;
33(3):693-694.
PMID: 32133836
No abstract available.