Lenguyen Huynh
Overview
Explore the profile of Lenguyen Huynh including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
395
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0
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Recent Articles
1.
Klisovic R, Blum W, Liu Z, Xie Z, Kefauver C, Huynh L, et al.
Leuk Lymphoma
. 2013 Sep;
55(6):1332-6.
PMID: 24015841
We hypothesized that GTI-2040, a 20-mer oligonucleotide complementary to the R2 subunit mRNA of ribonucleotide reductase, combined with high dose cytarabine (HiDAC) would result in enhanced cytotoxicity by favoring Ara-CTP...
2.
Alinari L, Mahoney E, Patton J, Zhang X, Huynh L, Earl C, et al.
Blood
. 2011 Nov;
118(26):6893-903.
PMID: 22042694
Mantle cell lymphoma (MCL) is an aggressive B-cell malignancy with a short median survival despite multimodal therapy. FTY720, an immunosuppressive drug approved for the treatment of multiple sclerosis, promotes MCL...
3.
Jin Y, Liu S, Yu B, Golan S, Koh C, Yang J, et al.
Mol Pharm
. 2009 Oct;
7(1):196-206.
PMID: 19852511
Therapeutic use of oligodeoxynucleotides (ODNs) that hybridize to and downregulate target mRNAs encoding proteins that contribute to malignant transformation has a sound rationale, but has had an overall limited clinical...
4.
Klisovic R, Blum W, Wei X, Liu S, Liu Z, Xie Z, et al.
Clin Cancer Res
. 2008 Jun;
14(12):3889-95.
PMID: 18559610
Purpose: Inhibition of ribonucleotide reductase reduces the availability of the endogenous pool of deoxycytidine and may increase cytarabine (AraC) cytotoxicity. We performed a phase I dose escalation trial of AraC...
5.
Liu S, Liu Z, Xie Z, Pang J, Yu J, Lehmann E, et al.
Blood
. 2007 Dec;
111(4):2364-73.
PMID: 18083845
Bortezomib reversibly inhibits 26S proteasomal degradation, interferes with NF-kappaB, and exhibits antitumor activity in human malignancies. Zinc finger protein Sp1 transactivates DNMT1 gene in mice and is functionally regulated through...
6.
Blum W, Klisovic R, Hackanson B, Liu Z, Liu S, Devine H, et al.
J Clin Oncol
. 2007 Aug;
25(25):3884-91.
PMID: 17679729
Purpose: To determine an optimal biologic dose (OBD) of decitabine as a single agent and then the maximum-tolerated dose (MTD) of valproic acid (VA) combined with decitabine in acute myeloid...
7.
Liu S, Klisovic R, Vukosavljevic T, Yu J, Paschka P, Huynh L, et al.
J Pharmacol Exp Ther
. 2007 Mar;
321(3):953-60.
PMID: 17389244
In t(8;21) acute myeloid leukemia (AML), the AML1/ETO fusion protein promotes leukemogenesis by recruiting class I histone deacetylase (HDAC)-containing repressor complex to the promoter of AML1 target genes. Valproic acid...
8.
Liu S, Shen T, Huynh L, Klisovic M, Rush L, Ford J, et al.
Cancer Res
. 2005 Mar;
65(4):1277-84.
PMID: 15735013
The translocation t(8;21)(q22;q22) in acute myeloid leukemia (AML) results in the expression of the fusion protein RUNX1/MTG8, which in turn recruits histone deacetylases (HDAC) to silence RUNX1 target genes [e.g.,...