Len Neckers
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Explore the profile of Len Neckers including associated specialties, affiliations and a list of published articles.
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167
Citations
9724
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Recent Articles
1.
Rastogi S, Joshi A, Sato N, Lee S, Lee M, Trepel J, et al.
Cell Stress Chaperones
. 2024 Jun;
29(4):519-539.
PMID: 38878853
The evolutionary conserved molecular chaperone heat shock protein 90 (HSP90) plays an indispensable role in tumorigenesis by stabilizing client oncoproteins. Although the functionality of HSP90 is tightly regulated, cancer cells...
2.
Sager R, Backe S, Neckers L, Woodford M, Mollapour M
Methods Mol Biol
. 2023 Aug;
2693:125-139.
PMID: 37540432
The molecular chaperone heat shock protein 90 (Hsp90) is essential in eukaryotes. Hsp90 chaperones proteins that are important determinants of multistep carcinogenesis. There are multiple Hsp90 isoforms including the cytosolic...
3.
Chiosis G, Digwal C, Trepel J, Neckers L
Nat Rev Mol Cell Biol
. 2023 Jul;
24(11):797-815.
PMID: 37524848
Heat shock protein 90 (HSP90) is a chaperone with vital roles in regulating proteostasis, long recognized for its function in protein folding and maturation. A view is emerging that identifies...
4.
van Oosten-Hawle P, Backe S, Ben-Zvi A, Bourboulia D, Brancaccio M, Brodsky J, et al.
Cell Stress Chaperones
. 2023 Jan;
28(1):1-9.
PMID: 36602710
The Second International Symposium on Cellular and Organismal Stress Responses took place virtually on September 8-9, 2022. This meeting was supported by the Cell Stress Society International (CSSI) and organized...
5.
Joshi A, Ito T, Picard D, Neckers L
Biomolecules
. 2022 Jul;
12(7).
PMID: 35883436
The HSP90 paralog TRAP1 was discovered more than 20 years ago; yet, a detailed understanding of the function of this mitochondrial molecular chaperone remains elusive. The dispensable nature of TRAP1...
6.
Inhibition of HSP 90 is associated with potent anti-tumor activity in Papillary Renal Cell Carcinoma
Pahwa R, Dubhashi J, Singh A, Jailwala P, Lobanov A, Thomas C, et al.
J Exp Clin Cancer Res
. 2022 Jun;
41(1):208.
PMID: 35754026
Background: There is no universally accepted treatment for patients with advanced papillary renal cell carcinoma (PRCC). The presence of activating mutations in MET, as well as gain of chromosome 7,...
7.
Shkedi A, Taylor I, Echtenkamp F, Ramkumar P, Alshalalfa M, Rivera-Marquez G, et al.
Cell Chem Biol
. 2022 Feb;
29(3):490-501.e4.
PMID: 35108506
Castration-resistant prostate cancer (CRPC) is associated with an increased reliance on heat shock protein 70 (HSP70), but it is not clear what other protein homeostasis (proteostasis) factors might be involved....
8.
Calderwood S, Repasky E, Neckers L, Hightower L
Cell Stress Chaperones
. 2022 Jan;
27(1):5-10.
PMID: 35060082
Single cell and multicellular organisms encounter physical stress from their environment as well as behavioral stress experienced in more complex organisms. As these stresses can present an existential threat, organisms...
9.
10.
Pipalia N, Saad S, Subramanian K, Cross A, Al-Motawa A, Garg K, et al.
J Lipid Res
. 2021 Sep;
62:100114.
PMID: 34481829
Niemann-Pick type C1 (NPC1) disease is a lysosomal lipid storage disorder caused by mutations of the NPC1 gene. More than 300 disease-associated mutations are reported in patients, resulting in abnormal...