Leigh M Sewall
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Explore the profile of Leigh M Sewall including associated specialties, affiliations and a list of published articles.
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23
Citations
377
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Recent Articles
1.
Brown S, Antanasijevic A, Sewall L, Garcia D, Brouwer P, Sanders R, et al.
Sci Immunol
. 2025 Jan;
10(103):eadp5218.
PMID: 39823319
Vaccination strategies against HIV-1 aim to elicit broadly neutralizing antibodies (bnAbs) using prime-boost regimens with HIV envelope (Env) immunogens. Epitope mapping has shown that early antibody responses are directed to...
2.
Bangaru S, Jackson A, Copps J, Fernandez-Quintero M, Torres J, Richey S, et al.
bioRxiv
. 2024 Dec;
PMID: 39713412
Current COVID-19 vaccines are largely limited in their ability to induce broad, durable immunity against emerging viral variants. Design and development of improved vaccines utilizing existing platforms requires an in-depth...
3.
Altman P, Ozorowski G, Stanfield R, Haakenson J, Appel M, Parren M, et al.
PLoS Pathog
. 2024 Sep;
20(9):e1012042.
PMID: 39250525
The generation of broadly neutralizing antibodies (bnAbs) to conserved epitopes on HIV Envelope (Env) is one of the cornerstones of HIV vaccine research. The animal models commonly used for HIV...
4.
Hahn W, Parks K, Shen M, Ozorowski G, Janes H, Ballweber-Fleming L, et al.
J Exp Med
. 2024 Sep;
221(10).
PMID: 39235529
Stabilized trimers preserving the native-like HIV envelope structure may be key components of a preventive HIV vaccine regimen to induce broadly neutralizing antibodies (bnAbs). We evaluated trimeric BG505 SOSIP.664 gp140...
5.
Nelson A, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, et al.
Sci Immunol
. 2024 Aug;
9(98):eadm7097.
PMID: 39213340
Adolescents are a growing population of people living with HIV. The period between weaning and sexual debut presents a low-risk window for HIV acquisition, making early childhood an ideal time...
6.
Cottrell C, Pratap P, Cirelli K, Carnathan D, Enemuo C, Antanasijevic A, et al.
NPJ Vaccines
. 2024 Jul;
9(1):126.
PMID: 38997302
Immunodominance of antibodies targeting non-neutralizing epitopes and the high level of somatic hypermutation within germinal centers (GCs) required for most HIV broadly neutralizing antibodies (bnAbs) are major impediments to the...
7.
Hahn W, Parks K, Shen M, Ozorowski G, Janes H, Ballweber-Fleming L, et al.
medRxiv
. 2024 May;
PMID: 38766048
Key Takeaway/take-home Messages: HIV BG505 SOSIP.664 trimer with novel 3M-052-AF/alum adjuvant in humans appears safe and induces serum neutralizing antibodies to matched clade A, tier 2 virus, that map to...
8.
Brown S, Antanasijevic A, Sewall L, Garcia D, Brouwer P, Sanders R, et al.
bioRxiv
. 2024 Apr;
PMID: 38559180
Vaccination strategies against HIV-1 aim to elicit broadly neutralizing antibodies (bnAbs) using prime-boost regimens with HIV envelope (Env) immunogens. Early antibody responses to easily accessible epitopes on these antigens are...
9.
Nelson A, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, et al.
bioRxiv
. 2023 Nov;
PMID: 37986885
A vaccine that can achieve protective immunity prior to sexual debut is critical to prevent the estimated 410,000 new HIV infections that occur yearly in adolescents. As children living with...
10.
Turner H, Jackson A, Richey S, Sewall L, Antanasijevic A, Hangartner L, et al.
STAR Protoc
. 2023 Jul;
4(3):102476.
PMID: 37516970
Electron microscopy-based polyclonal epitope mapping (EMPEM) can delineate epitope specificities of serum antibodies to a given antigen following vaccination or infection. Here, we present a protocol for the EMPEM method...