Leigh M Sewall
Overview
Explore the profile of Leigh M Sewall including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
23
Citations
377
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Torrents de la Pena A, Sewall L, de Paiva Froes Rocha R, Jackson A, Pratap P, Bangaru S, et al.
Cell Rep Methods
. 2023 Jul;
3(6):100509.
PMID: 37426749
Understanding antibody-antigen interactions in a polyclonal immune response in humans and animal models is critical for rational vaccine design. Current approaches typically characterize antibodies that are functionally relevant or highly...
12.
Cottrell C, Pratap P, Cirelli K, Carnathan D, Enemuo C, Antanasijevic A, et al.
bioRxiv
. 2023 Jul;
PMID: 37425865
Immunodominance of antibodies targeting non-neutralizing epitopes and the high level of somatic hypermutation within germinal centers (GCs) required for most HIV broadly neutralizing antibodies (bnAbs) are major impediments to the...
13.
Lee J, Sutton H, Cottrell C, Phung I, Ozorowski G, Sewall L, et al.
Nature
. 2023 Jan;
614(7949):E43.
PMID: 36717721
No abstract available.
14.
Lee J, Sutton H, Cottrell C, Phung I, Ozorowski G, Sewall L, et al.
Nature
. 2022 Sep;
609(7929):998-1004.
PMID: 36131022
Germinal centres are the engines of antibody evolution. Here, using human immunodeficiency virus (HIV) Env protein immunogen priming in rhesus monkeys followed by a long period without further immunization, we...
15.
Zhao F, Berndsen Z, Pedreno-Lopez N, Burns A, Allen J, Barman S, et al.
Nat Commun
. 2022 Sep;
13(1):5236.
PMID: 36068229
SIVmac239 infection of macaques is a favored model of human HIV infection. However, the SIVmac239 envelope (Env) trimer structure, glycan occupancy, and the targets and ability of neutralizing antibodies (nAbs)...
16.
Bangaru S, Antanasijevic A, Kose N, Sewall L, Jackson A, Suryadevara N, et al.
Sci Adv
. 2022 May;
8(18):eabn2911.
PMID: 35507649
Preexisting immunity against seasonal coronaviruses (CoVs) represents an important variable in predicting antibody responses and disease severity to severe acute respiratory syndrome CoV-2 (SARS-CoV-2) infections. We used electron microscopy-based polyclonal...
17.
Antanasijevic A, Bowman C, Kirchdoerfer R, Cottrell C, Ozorowski G, Upadhyay A, et al.
Sci Adv
. 2022 Jan;
8(3):eabk2039.
PMID: 35044813
One of the rate-limiting steps in analyzing immune responses to vaccines or infections is the isolation and characterization of monoclonal antibodies. Here, we present a hybrid structural and bioinformatic approach...
18.
Antanasijevic A, Sewall L, Cottrell C, Carnathan D, Jimenez L, Ngo J, et al.
Nat Commun
. 2021 Aug;
12(1):4817.
PMID: 34376662
Engineered ectodomain trimer immunogens based on BG505 envelope glycoprotein are widely utilized as components of HIV vaccine development platforms. In this study, we used rhesus macaques to evaluate the immunogenicity...
19.
Kumar R, Deshpande S, Sewall L, Ozorowski G, Cottrell C, Lee W, et al.
PLoS Pathog
. 2021 Apr;
17(4):e1008977.
PMID: 33826683
Evaluating the structure-function relationship of viral envelope (Env) evolution and the development of broadly cross-neutralizing antibodies (bnAbs) in natural infection can inform rational immunogen design. In the present study, we...
20.
Charles T, Burton S, Arunachalam P, Cottrell C, Sewall L, Bollimpelli V, et al.
PLoS Pathog
. 2021 Feb;
17(2):e1009257.
PMID: 33556148
Stabilized HIV-1 envelope (Env) trimers elicit tier 2 autologous neutralizing antibody (nAb) responses in immunized animals. We previously demonstrated that BG505 SOSIP.664.T332N gp140 (BG505 SOSIP) immunization of rhesus macaques (RM)...