HIV BG505 SOSIP.664 Trimer with 3M-052-AF/alum Induces Human Autologous Tier-2 Neutralizing Antibodies
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Abstract
Key Takeaway/take-home Messages: HIV BG505 SOSIP.664 trimer with novel 3M-052-AF/alum adjuvant in humans appears safe and induces serum neutralizing antibodies to matched clade A, tier 2 virus, that map to diverse Env epitopes with relatively high titers. The novel adjuvant may be an important mediator of vaccine response.