Lefu Lan
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Explore the profile of Lefu Lan including associated specialties, affiliations and a list of published articles.
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82
Citations
2072
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Recent Articles
1.
Zhou H, Yuan Z, Guan X, Yue C, Wu W, Lan L, et al.
Chemistry
. 2025 Mar;
:e202500464.
PMID: 40072260
Sortase A (SrtA), a cysteine transpeptidase critical for surface protein anchoring in Gram-positive pathogens, represents an attractive antivirulence target. While covalent SrtA inhibitors show therapeutic potential, existing compounds lack species...
2.
Ma W, Luo J, Liu H, Du Q, Hao T, Jiang Y, et al.
Angew Chem Int Ed Engl
. 2025 Feb;
:e202424312.
PMID: 39996424
MUC7, a highly glycosylated protein in saliva and respiratory tract, plays potential roles in facilitating bacterial clearance and preventing microbial invasion. The complexity of glycan structures and multiplicity of glycosylation...
3.
Zhang T, Wu W, Zhao Y, Ding Z, Wei B, Yang T, et al.
J Med Chem
. 2025 Jan;
68(2):1810-1823.
PMID: 39760203
Peritonitis caused by poses a severe threat to patients with end-stage renal failure. Treating multidrug-resistant infections requires the use of antibiotics with diverse mechanisms of action. Caseinolytic protease P (ClpP)...
4.
Wang K, Ouyang J, Liu H, Yin L, Yang K, Lan L, et al.
J Org Chem
. 2024 Dec;
89(24):18746-18751.
PMID: 39656155
A novel method is reported to synthesize various pyrazolones through transition-metal-free and redox-neutral 1°, 2°, or 3° C(sp)-H carbonylative cyclization using 1 atm of CO as a green carbonyl source,...
5.
Zhang T, Wang P, Zhou H, Wei B, Zhao Y, Li J, et al.
Cell Rep Med
. 2024 Nov;
5(12):101837.
PMID: 39615486
Methicillin-resistant Staphylococcus aureus is a ubiquitous pathogen, posing a serious threat to human health worldwide. Thus, there is a high demand for antibiotics with distinct targets. Caseinolytic protease P (ClpP)...
6.
Chen F, Zhao Q, Yang Z, Chen R, Pan H, Wang Y, et al.
PLoS Pathog
. 2024 Jul;
20(7):e1012425.
PMID: 39078849
Pathogenic bacteria's metabolic adaptation for survival and proliferation within hosts is a crucial aspect of bacterial pathogenesis. Here, we demonstrate that citrate, the first intermediate of the tricarboxylic acid (TCA)...
7.
Guan D, Liu J, Chen F, Li J, Wang X, Lu W, et al.
J Med Chem
. 2024 Apr;
67(7):5958-5959.
PMID: 38564651
No abstract available.
8.
Guan D, Liu J, Chen F, Li J, Wang X, Lu W, et al.
J Med Chem
. 2024 Mar;
67(5):3778-3794.
PMID: 38482826
It is an urgent need to tackle the global crisis of multidrug-resistant bacterial infections. We report here an innovative strategy for large-scale screening of new antibacterial agents using a whole...
9.
Zhong Y, Liu H, Chen F, He Q, Zhang X, Lan L, et al.
Eur J Med Chem
. 2024 Feb;
268:116221.
PMID: 38382392
The formation of biofilm is one of the important factors for bacteria to develop drug-resistant. A series of halogenated-pyrroles or pyrazoles containing thiazole groups as antibacterial agents were designed and...
10.
Zhou H, Kang Y, Tang D, Lan L
Front Pharmacol
. 2023 Dec;
14:1339116.
PMID: 38125885
No abstract available.