Cai-Guang Yang
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Explore the profile of Cai-Guang Yang including associated specialties, affiliations and a list of published articles.
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85
Citations
3478
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Recent Articles
1.
Fu X, Yu P, Long Z, Feng Y, Sun Z, Zhou X, et al.
Int J Biol Macromol
. 2025 Mar;
:141866.
PMID: 40074108
Caseinolytic protease P (ClpP) protein is essential for prokaryotic and eukaryotic protein homeostasis, and has emerged as a promising bactericidal target for controlling bacterial infection and evading the emergent of...
2.
Zhou H, Yuan Z, Guan X, Yue C, Wu W, Lan L, et al.
Chemistry
. 2025 Mar;
:e202500464.
PMID: 40072260
Sortase A (SrtA), a cysteine transpeptidase critical for surface protein anchoring in Gram-positive pathogens, represents an attractive antivirulence target. While covalent SrtA inhibitors show therapeutic potential, existing compounds lack species...
3.
Dong Z, Huang Y, Xia W, Liao Y, Yang C
Expert Opin Ther Pat
. 2025 Mar;
:1-10.
PMID: 40052926
Introduction: The fat mass and obesity-associated protein (FTO) catalytically demethylates RNA N-methyl adenosine (mA) modification, dynamically regulates gene expression in eukaryotes. Interestingly, FTO is highly expressed and functions as an...
4.
Zhang D, Liu L, Li M, Hu X, Zhang X, Xia W, et al.
Eur J Med Chem
. 2025 Mar;
289:117444.
PMID: 40022879
Fat mass and obesity-associated protein (FTO) is the first discovered RNA N-methyladenosine (mA) demethylase. The highly expressed FTO protein is required to trigger oncogenic pathways in acute myeloid leukemia (AML),...
5.
Wu H, Lai G, Cheng R, Huang H, Wang J, Liu Z, et al.
Angew Chem Int Ed Engl
. 2025 Feb;
:e202424928.
PMID: 39976119
The N-methyladenosine (mA) demethylase ALKBH5 is the only other identified mA eraser except for FTO, and dysregulated ALKBH5 functions were closely associated with leukemogenesis. However, the development of ALKBH5 inhibitors...
6.
Liang X, Huang Y, Ren H, Liu Q, Chen L, Zhao J, et al.
J Med Chem
. 2025 Jan;
68(3):2742-2763.
PMID: 39818964
Fat mass obesity-associated protein (FTO) has been emerging as a potential therapeutic target for drug discovery in RNA epigenetics. In this work, a series of novel FTO inhibitors featuring an...
7.
Liu L, Qiu Y, Suo Y, Tong S, Wang Y, Zhang X, et al.
Acta Pharm Sin B
. 2025 Jan;
14(12):5382-5392.
PMID: 39807332
The fat mass and obesity-associated protein (FTO) is an RNA demethylase required for catalytic demethylation of -methyladenosine (mA); it is highly expressed and functions as an oncogene in acute myeloid...
8.
Zhang T, Wu W, Zhao Y, Ding Z, Wei B, Yang T, et al.
J Med Chem
. 2025 Jan;
68(2):1810-1823.
PMID: 39760203
Peritonitis caused by poses a severe threat to patients with end-stage renal failure. Treating multidrug-resistant infections requires the use of antibiotics with diverse mechanisms of action. Caseinolytic protease P (ClpP)...
9.
Wang H, Tang S, Wu Q, He Y, Zhu W, Xie X, et al.
Natl Sci Rev
. 2024 Dec;
11(12):nwae392.
PMID: 39687207
Although adeno-to-squamous transition (AST) has been observed in association with resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) in clinic, its causality, molecular mechanism and overcoming strategies...
10.
Zhang T, Wang P, Zhou H, Wei B, Zhao Y, Li J, et al.
Cell Rep Med
. 2024 Nov;
5(12):101837.
PMID: 39615486
Methicillin-resistant Staphylococcus aureus is a ubiquitous pathogen, posing a serious threat to human health worldwide. Thus, there is a high demand for antibiotics with distinct targets. Caseinolytic protease P (ClpP)...