Lee W Page
Overview
Explore the profile of Lee W Page including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
9
Citations
68
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Johnson C, Ahn J, Buck I, Chiarparin E, Day J, Hopkins A, et al.
J Med Chem
. 2018 Aug;
61(16):7314-7329.
PMID: 30091600
Inhibitor of apoptosis proteins (IAPs) are promising anticancer targets, given their roles in the evasion of apoptosis. Several peptidomimetic IAP antagonists, with inherent selectivity for cellular IAP (cIAP) over X-linked...
2.
Woolford A, Day P, Beneton V, Berdini V, Coyle J, Dudit Y, et al.
J Med Chem
. 2016 Dec;
59(23):10738-10749.
PMID: 27933945
Lp-PLA has been explored as a target for a number of inflammation associated diseases, including cardiovascular disease and dementia. This article describes the discovery of a new fragment derived chemotype...
3.
Woolford A, Pero J, Aravapalli S, Berdini V, Coyle J, Day P, et al.
J Med Chem
. 2016 May;
59(11):5356-67.
PMID: 27167608
Elevated levels of human lipoprotein-associated phospholipase A2 (Lp-PLA2) are associated with cardiovascular disease and dementia. A fragment screen was conducted against Lp-PLA2 in order to identify novel inhibitors. Multiple fragment...
4.
Murray C, Berdini V, Buck I, Carr M, Cleasby A, Coyle J, et al.
ACS Med Chem Lett
. 2015 Jul;
6(7):798-803.
PMID: 26191369
The DDR1 and DDR2 receptor tyrosine kinases are activated by extracellular collagen and have been implicated in a number of human diseases including cancer. We performed a fragment-based screen against...
5.
Feast G, Page L, Robertson J
Chem Commun (Camb)
. 2010 Apr;
46(16):2835-7.
PMID: 20369199
Rhodium-bound nitrenoids are trapped by tethered allenes generating acyloxy-enamines, aminocyclopropanes, and methylene aziridines. The aminocyclopropanes undergo substitution of the acetoxy group by a variety of nucleophiles.
6.
Gleave R, Beswick P, Brown A, Giblin G, Goldsmith P, Haslam C, et al.
Bioorg Med Chem Lett
. 2009 Dec;
20(2):465-8.
PMID: 20005703
A series of 3-amino-6-aryl-pyridazines have been identified as CB(2) agonists with high efficacy and selectivity against the CB(1) receptor. Details of the investigation of structure-activity relationships (SAR) are disclosed, which...
7.
Feast G, Haestier J, Page L, Robertson J, Thompson A, Watkin D
Acta Crystallogr C
. 2009 Dec;
65(Pt 12):o635-8.
PMID: 19966448
The unusual methylene aziridine 6-tert-butyl-3-oxa-2-thia-1-azabicyclo[5.1.0]oct-6-ene 2,2-dioxide, C(9)H(15)NO(3)S, was found to crystallize with two molecules in the asymmetric unit. The structure was solved in both the approximately orthogonal and the oblique...
8.
Gleave R, Beswick P, Brown A, Giblin G, Haslam C, Livermore D, et al.
Bioorg Med Chem Lett
. 2009 Oct;
19(23):6578-81.
PMID: 19864133
2-Amino-5-aryl-pyridines, exemplified by compound 1, had been identified as a synthetically tractable series of CB(2) agonists from a high-throughput screen of the GlaxoSmithKline compound collection. Described herein are the results...
9.
Swarbrick M, Beswick P, Gleave R, Green R, Bingham S, Bountra C, et al.
Bioorg Med Chem Lett
. 2009 Jun;
19(15):4504-8.
PMID: 19520573
A novel series of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidine-based cyclooxygenase-2 (COX-2) inhibitors, which have a different arrangement of substituents compared to the more common 1,2-diarylheterocycle based molecules, have been discovered. For example, 2-(butyloxy)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine (47),...