Lydia Y W Lee
Overview
Explore the profile of Lydia Y W Lee including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
103
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0
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Recent Articles
1.
Quevedo C, Cruz-Migoni A, Bery N, Miller A, Tanaka T, Petch D, et al.
Nat Commun
. 2018 Aug;
9(1):3169.
PMID: 30093669
Targeting specific protein-protein interactions (PPIs) is an attractive concept for drug development, but hard to implement since intracellular antibodies do not penetrate cells and most small-molecule drugs are considered unsuitable...
2.
Woolford A, Day P, Beneton V, Berdini V, Coyle J, Dudit Y, et al.
J Med Chem
. 2016 Dec;
59(23):10738-10749.
PMID: 27933945
Lp-PLA has been explored as a target for a number of inflammation associated diseases, including cardiovascular disease and dementia. This article describes the discovery of a new fragment derived chemotype...
3.
Woolford A, Pero J, Aravapalli S, Berdini V, Coyle J, Day P, et al.
J Med Chem
. 2016 May;
59(11):5356-67.
PMID: 27167608
Elevated levels of human lipoprotein-associated phospholipase A2 (Lp-PLA2) are associated with cardiovascular disease and dementia. A fragment screen was conducted against Lp-PLA2 in order to identify novel inhibitors. Multiple fragment...
4.
Murray C, Berdini V, Buck I, Carr M, Cleasby A, Coyle J, et al.
ACS Med Chem Lett
. 2015 Jul;
6(7):798-803.
PMID: 26191369
The DDR1 and DDR2 receptor tyrosine kinases are activated by extracellular collagen and have been implicated in a number of human diseases including cancer. We performed a fragment-based screen against...
5.
Paterson I, Fink S, Lee L, Atkinson S, Blakey S
Org Lett
. 2013 Jun;
15(12):3118-21.
PMID: 23730909
A highly stereocontrolled total synthesis of the cytotoxic marine macrolide aplyronine C is described. The route exploits aldol methodology to install the requisite stereochemistry and features a crucial boron-mediated aldol...
6.
Lee L, Hupfield T, Nicholson R, Hodgkinson J, Su X, Thomas G, et al.
Mol Biosyst
. 2008 May;
4(6):505-7.
PMID: 18493644
Diastereomeric 2-methoxycyclopentyl analogues of a natural quorum sensing signaling molecule from Pseudomonas aeruginosa were synthesized and screened in pigment production assays with P. aeruginosa and Serratia strain ATCC39006.