Lee Hopkins
Overview
Explore the profile of Lee Hopkins including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
665
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0
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Recent Articles
1.
Li B, Ponjavic A, Chen W, Hopkins L, Hughes C, Ye Y, et al.
Anal Chem
. 2021 Feb;
93(8):4092-4099.
PMID: 33595281
The detection of single molecules in biological systems has rapidly increased in resolution over the past decade. However, the delivery of single molecules remains to be a challenge. Currently, there...
2.
Moncrieffe M, Bollschweiler D, Li B, Penczek P, Hopkins L, Bryant C, et al.
Structure
. 2020 Jan;
28(3):281-289.e3.
PMID: 31995744
Toll-like receptors (TLRs) are pivotal in triggering the innate immune response to pathogen infection. Ligand binding induces receptor dimerization which facilitates the recruitment of other post-receptor signal transducers into a...
3.
Hughes C, Choi M, Ryten M, Hopkins L, Drews A, Botia J, et al.
Acta Neuropathol
. 2018 Oct;
137(1):121.
PMID: 30328509
In the original publication of this article, the author Magarida Rodrigues was written incorrectly.
4.
Hughes C, Choi M, Ryten M, Hopkins L, Drews A, Botia J, et al.
Acta Neuropathol
. 2018 Sep;
137(1):103-120.
PMID: 30225556
Despite the wealth of genomic and transcriptomic data in Parkinson's disease (PD), the initial molecular events are unknown. Using LD score regression analysis, we show significant enrichment in PD heritability...
5.
Latty S, Sakai J, Hopkins L, Verstak B, Paramo T, Berglund N, et al.
Elife
. 2018 Jan;
7.
PMID: 29368691
Infection and tissue damage induces assembly of supramolecular organizing centres (SMOCs)), such as the Toll-like receptor (TLR) MyDDosome, to co-ordinate inflammatory signaling. SMOC assembly is thought to drive digital all-or-none...
6.
Jabir M, Hopkins L, Ritchie N, Ullah I, Bayes H, Li D, et al.
Autophagy
. 2015 Feb;
11(1):166-82.
PMID: 25700738
The nucleotide-binding domain, leucine-rich repeat containing family caspase recruitment domain containing 4 (NLRC4) inflammasome can be activated by pathogenic bacteria via products translocated through the microbial type III secretion apparatus...
7.
Yang S, Thackray A, Hopkins L, Monie T, Burke D, Bujdoso R
Biomed Res Int
. 2014 Aug;
2014:372491.
PMID: 25126555
Polymorphisms in ovine PrP at amino acid residues 141 and 154 are associated with susceptibility to ovine prion disease: Leu141Arg154 with classical scrapie and Phe141Arg154 and Leu141His154 with atypical scrapie....
8.
Jabir M, Ritchie N, Li D, Bayes H, Tourlomousis P, Puleston D, et al.
Cell Host Microbe
. 2014 Feb;
15(2):214-27.
PMID: 24528867
Bacterial infection can trigger autophagy and inflammasome activation, but the effects of inflammasome activation on autophagy are unknown. We examined this in the context of Pseudomonas aeruginosa macrophage infection, which...
9.
Man S, Tourlomousis P, Hopkins L, Monie T, Fitzgerald K, Bryant C
J Immunol
. 2013 Oct;
191(10):5239-46.
PMID: 24123685
Nucleotide-binding oligomerization domain-like receptors (NLRs) detect pathogens and danger-associated signals within the cell. Salmonella enterica serovar Typhimurium, an intracellular pathogen, activates caspase-1 required for the processing of the proinflammatory cytokines,...
10.
Herre J, Gronlund H, Brooks H, Hopkins L, Waggoner L, Murton B, et al.
J Immunol
. 2013 Jul;
191(4):1529-35.
PMID: 23878318
Allergic responses can be triggered by structurally diverse allergens. Most allergens are proteins, yet extensive research has not revealed how they initiate the allergic response and why the myriad of...