Lee Hopkins
Overview
Explore the profile of Lee Hopkins including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
18
Citations
665
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Thackray A, Hopkins L, Lockey R, Spiropoulos J, Bujdoso R
Exp Mol Pathol
. 2011 Nov;
92(1):167-74.
PMID: 22120785
Ovine prion strains have typically been identified by their transmission properties, which include incubation time and lesion profile, in wild type mice. The existence of scrapie isolates that do not...
12.
Thackray A, Hopkins L, Lockey R, Spiropoulos J, Bujdoso R
J Gen Virol
. 2011 Jan;
92(Pt 6):1482-1491.
PMID: 21270287
The infectious agent associated with prion diseases such as ovine scrapie shows strain diversity. Ovine prion strains have typically been identified by their transmission properties in wild-type mice. However, strain...
13.
Barnard G, Hopkins L, Moorthie S, Seilly D, Tonks P, Dabaghian R, et al.
Prion
. 2009 Jan;
1(2):121-7.
PMID: 19164886
A simple diagnostic test is described for the detection of TSE in bovine, ovine and human brain and lymphoid tissue that obviates the use of proteinase K as a discriminating...
14.
Thackray A, Hopkins L, Spiropoulos J, Bujdoso R
J Virol
. 2008 Sep;
82(22):11197-207.
PMID: 18768980
A more complete assessment of ovine prion strain diversity will be achieved by complementing biological strain typing in conventional and ovine PrP transgenic mice with a biochemical analysis of the...
15.
Fitzmaurice T, Burke D, Hopkins L, Yang S, Yu S, Sy M, et al.
Biochem J
. 2007 Oct;
409(2):367-75.
PMID: 17931166
Susceptibility to scrapie disease in sheep, the archetypal prion disease, correlates with polymorphisms within the ovine PrP (prion-related protein) gene. The VRQ (Val136Arg154Gln171) and AL141RQ (Ala136Leu141Arg154Gln171) allelic variants are associated...
16.
Thackray A, Hopkins L, Klein M, Bujdoso R
J Virol
. 2007 Aug;
81(22):12119-27.
PMID: 17728226
The agent responsible for prion disease may exist in different forms, commonly referred to as strains, with each carrying the specific information that determines its own distinct biological properties, such...
17.
Thackray A, Hopkins L, Bujdoso R
Biochem J
. 2006 Oct;
401(2):475-83.
PMID: 17018021
PrPSc [abnormal disease-specific conformation of PrP (prion-related protein)] accumulates in prion-affected individuals in the form of amorphous aggregates. Limited proteolysis of PrPSc results in a protease-resistant core of PrPSc of...
18.
Thackray A, Fitzmaurice T, Hopkins L, Bujdoso R
Biochem J
. 2006 Aug;
400(2):349-58.
PMID: 16881870
Ovine PBMCs (peripheral blood mononuclear cells) express PrP(C) [cellular PrP (prion-related protein)] and have the potential to harbour and release disease-associated forms of PrP during scrapie in sheep. Cell-surface PrP(C)...