Clare E Bryant
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Explore the profile of Clare E Bryant including associated specialties, affiliations and a list of published articles.
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110
Citations
4719
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Recent Articles
1.
Sardar P, Beresford-Jones B, Xia W, Shabana O, Suyama S, Ramos R, et al.
Nat Microbiol
. 2025 Feb;
10(3):795-807.
PMID: 39929976
The gut microbiome modulates immunotherapy treatment responses, and this may explain why immune checkpoint inhibitors, such as anti-PD-1, are only effective in some patients. Previous studies correlated lipopolysaccharide (LPS)-producing gut...
2.
Flower L, Vozza E, Bryant C, Summers C
Thorax
. 2025 Jan;
PMID: 39884849
Acute respiratory distress syndrome (ARDS) is present in >10% of all people admitted to critical care and is associated with severe morbidity and mortality. Despite more than half a century...
3.
Bryant C
Curr Opin Immunol
. 2024 Sep;
91:102460.
PMID: 39288726
Since the discovery of Toll and Toll-like receptors (TLRs) in the 90s, an extensive body of research has been performed to determine how Pattern Recognition Receptors (PRRs) recognise 'ligands' and...
4.
Welch L, Estranero J, Tourlomousis P, Wootton R, Radu V, Gonzalez-Fernandez C, et al.
Lab Chip
. 2024 Jul;
24(16):3763-3774.
PMID: 39037291
Recently, there has been an increasing emphasis on single cell profiling for high-throughput screening workflows in drug discovery and life sciences research. However, the biology underpinning these screens is often...
5.
Li B, Suresh P, Brelstaff J, Kedia S, Bryant C, Klenerman D
Elife
. 2024 Jun;
13.
PMID: 38864842
The Myddosome is a key innate immune signalling platform. It forms at the cell surface and contains MyD88 and IRAK proteins which ultimately coordinate the production of pro-inflammatory cytokines. Toll-like...
6.
Davies B, Crew R, Cochrane A, Davies K, Figueiredo Baptista A, Jeckel S, et al.
J Anat
. 2024 May;
245(3):405-419.
PMID: 38735860
The specific biology of the male breast remains relatively unexplored in spite of the increasing global prevalence of male breast cancer. Delineation of the microenvironment of the male breast is...
7.
Pereira M, Liang J, Edwards-Hicks J, Meadows A, Hinz C, Liggi S, et al.
Cell Rep
. 2024 Jan;
43(2):113700.
PMID: 38265935
Elevated interleukin (IL)-1β levels, NLRP3 inflammasome activity, and systemic inflammation are hallmarks of chronic metabolic inflammatory syndromes, but the mechanistic basis for this is unclear. Here, we show that levels...
8.
Bezbradica J, Bryant C
EMBO Rep
. 2024 Jan;
25(1):21-30.
PMID: 38177903
Mechano-immunity, the intersection between cellular or tissue mechanics and immune cell function, is emerging as an important factor in many inflammatory diseases. Mechano-sensing defines how cells detect mechanical changes in...
9.
Guabiraba R, Rodrigues D, Manna P, Chollot M, Saint-Martin V, Trapp S, et al.
Dev Comp Immunol
. 2023 Nov;
151:105093.
PMID: 37951324
The innate immune response relies on the ability of host cells to rapidly detect and respond to microbial nucleic acids. Toll-like receptors (TLRs), a class of pattern recognition receptors (PRRs),...
10.
Liu Y, Zhai H, Alemayehu H, Boulanger J, Hopkins L, Borgeaud A, et al.
Nat Commun
. 2023 Nov;
14(1):7246.
PMID: 37945612
NLRP3 induces caspase-1-dependent pyroptotic cell death to drive inflammation. Aberrant activity of NLRP3 occurs in many human diseases. NLRP3 activation induces ASC polymerization into a single, micron-scale perinuclear punctum. Higher...