Ledong Wan
Overview
Explore the profile of Ledong Wan including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
622
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Recent Articles
1.
Coughlin Jr K, Wan L
J Exp Med
. 2025 Feb;
222(5).
PMID: 39992625
In this issue of JEM, Krishnamoorthy et al. (https://doi.org/10.1084/jem.20241029) identify the loss of the splicing factor RBM10 as a driver of metastasis in thyroid cancer through the regulation of RNA...
2.
Maia-Silva D, Cunniff P, Schier A, Skopelitis D, Trousdell M, Moresco P, et al.
Nat Genet
. 2024 Jun;
56(7):1377-1385.
PMID: 38886586
The presence of basal lineage characteristics signifies hyperaggressive human adenocarcinomas of the breast, bladder and pancreas. However, the biochemical mechanisms that maintain this aberrant cell state are poorly understood. Here...
3.
Wan L, Kral A, Voss D, Schafer B, Sudheendran K, Danielsen M, et al.
Nucleic Acid Ther
. 2024 May;
34(4):188-198.
PMID: 38716830
Aberrant alternative splicing is emerging as a cancer hallmark and a potential therapeutic target. It is the result of dysregulated or mutated splicing factors, or genetic alterations in splicing-regulatory -elements....
4.
He X, Gao Y, Ng D, Michalopoulou E, George S, Adrover J, et al.
Cancer Cell
. 2024 Feb;
42(3):474-486.e12.
PMID: 38402610
Chronic stress is associated with increased risk of metastasis and poor survival in cancer patients, yet the reasons are unclear. We show that chronic stress increases lung metastasis from disseminated...
5.
Islam M, Nagar P, Neetole S, Wan L, Rahman M
Genes (Basel)
. 2023 Nov;
14(11).
PMID: 38002963
Since the discovery of RNA splicing as a fundamental step to remove introns from pre-mRNA to produce mature mRNAs, substantial research in the past decades has highlighted RNA splicing as...
6.
Wan L, Lin K, Rahman M, Ishigami Y, Wang Z, Jensen M, et al.
Cancer Discov
. 2023 Apr;
13(7):1678-1695.
PMID: 37098965
Significance: We describe the regulation of splicing factor SRSF1 expression in the context of pancreas cell identity, plasticity, and inflammation. SRSF1 protein downregulation is involved in a negative feedback cellular...
7.
Wan L, Kral A, Voss D, Krainer A
bioRxiv
. 2023 Apr;
PMID: 37066201
Aberrant alternative splicing is emerging as a cancer hallmark and a potential therapeutic target. It is the result of dysregulated splicing factors or genetic alterations in splicing-regulatory -elements. Targeting individual...
8.
Wan L, Deng M, Zhang H
Genes (Basel)
. 2022 Sep;
13(9).
PMID: 36140826
Substantial emerging evidence supports that dysregulated RNA metabolism is associated with tumor initiation and development. Serine/Arginine-Rich proteins (SR) are a number of ultraconserved and structurally related proteins that contain a...
9.
Zhu Y, Lu H, Zhang D, Li M, Sun X, Wan L, et al.
Clin Epigenetics
. 2018 Mar;
10:30.
PMID: 29507648
Background: DNA methylation is an important epigenetic modification, associated with gene expression. 5-Methylcytosine and 5-hydroxymethylcytosine are two epigenetic hallmarks that maintain the equilibrium of epigenetic reprogramming. Disequilibrium in genomic methylation...
10.
Wan L, Yu W, Shen E, Sun W, Liu Y, Kong J, et al.
Gut
. 2017 Nov;
68(1):118-129.
PMID: 29114070
Objective: To investigate the molecular function of splicing factor SRSF6 in colorectal cancer (CRC) progression and discover candidate chemicals for cancer therapy through targeting SRSF6. Design: We performed comprehensive analysis...