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Leanna Whitmore

Explore the profile of Leanna Whitmore including associated specialties, affiliations and a list of published articles. Areas
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Articles 10
Citations 637
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Recent Articles
1.
Martin-Vilchez S, Whitmore L, Asmussen H, Zareno J, Horwitz R, Newell-Litwa K
PLoS One . 2017 Jan; 12(1):e0170464. PMID: 28114311
Small RhoGTPases regulate changes in post-synaptic spine morphology and density that support learning and memory. They are also major targets of synaptic disorders, including Autism. Here we sought to determine...
2.
Newell-Litwa K, Badoual M, Asmussen H, Patel H, Whitmore L, Horwitz A
J Cell Biol . 2015 Jul; 210(2):225-42. PMID: 26169356
RhoGTPases organize the actin cytoskeleton to generate diverse polarities, from front-back polarity in migrating cells to dendritic spine morphology in neurons. For example, RhoA through its effector kinase, RhoA kinase...
3.
Vicente-Manzanares M, Koach M, Whitmore L, Lamers M, Horwitz A
J Cell Biol . 2008 Oct; 183(3):543-54. PMID: 18955554
We have found that MLC-dependent activation of myosin IIB in migrating cells is required to form an extended rear, which coincides with increased directional migration. Activated myosin IIB localizes prominently...
4.
Vicente-Manzanares M, Zareno J, Whitmore L, Choi C, Horwitz A
J Cell Biol . 2007 Feb; 176(5):573-80. PMID: 17312025
We have used isoform-specific RNA interference knockdowns to investigate the roles of myosin IIA (MIIA) and MIIB in the component processes that drive cell migration. Both isoforms reside outside of...
5.
Brown C, Hebert B, Kolin D, Zareno J, Whitmore L, Horwitz A, et al.
J Cell Sci . 2006 Dec; 119(Pt 24):5204-14. PMID: 17158922
Cell migration is regulated in part by the connection between the substratum and the actin cytoskeleton. However, the very large number of proteins involved in this linkage and their complex...
6.
Mayhew M, Webb D, Kovalenko M, Whitmore L, Fox J, Horwitz A
J Proteome Res . 2006 Sep; 5(9):2417-23. PMID: 16944954
The process of cell motility involves coordinate signaling events among proteins associated in interactive integrin-linked networks. Mass spectrometric analysis of immunoprecipitation-derived protein mixtures have provided efficient means of identifying proteomes....
7.
Webb D, Mayhew M, Kovalenko M, Schroeder M, Jeffery E, Whitmore L, et al.
J Cell Sci . 2006 Jul; 119(Pt 14):2847-50. PMID: 16825424
No abstract available.
8.
Webb D, Kovalenko M, Whitmore L, Horwitz A
Biochem Biophys Res Commun . 2006 Jun; 346(4):1284-8. PMID: 16797488
G protein-coupled receptor kinase-interacting protein (GIT)1 is a multidomain, adaptor protein that regulates cellular processes, such as migration and protrusive activity, by bringing together various signaling molecules, including PIX, PAK,...
9.
Webb D, Schroeder M, Brame C, Whitmore L, Shabanowitz J, Hunt D, et al.
J Cell Sci . 2005 Oct; 118(Pt 21):4925-9. PMID: 16254239
No abstract available.
10.
Manabe R, Whitmore L, Weiss J, Horwitz A
Curr Biol . 2002 Nov; 12(22):1946-51. PMID: 12445389
Microtubules play critical roles in a variety of cell processes, including mitosis, organelle transport, adhesion and migration, and the maintenance of cell polarity. Microtubule-associated proteins (MAPs) regulate the dynamic organization...