Alan Rick Horwitz
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Explore the profile of Alan Rick Horwitz including associated specialties, affiliations and a list of published articles.
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37
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6584
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Recent Articles
1.
Bachir A, Horwitz A, Nelson W, Bianchini J
Cold Spring Harb Perspect Biol
. 2017 Jul;
9(7).
PMID: 28679638
Cell adhesions link cells to the extracellular matrix (ECM) and to each other and depend on interactions with the actin cytoskeleton. Both cell-ECM and cell-cell adhesion sites contain discrete, yet...
2.
de Oliveira Ramos G, Bernardi L, Lauxen I, Filho M, Horwitz A, Lamers M
PLoS One
. 2016 Mar;
11(3):e0151338.
PMID: 26978651
Cell migration is regulated by adhesion to the extracellular matrix (ECM) through integrins and activation of small RhoGTPases, such as RhoA and Rac1, resulting in changes to actomyosin organization. During...
3.
Devreotes P, Horwitz A
Cold Spring Harb Perspect Biol
. 2015 Aug;
7(8):a005959.
PMID: 26238352
Stimuli that promote cell migration, such as chemokines, cytokines, and growth factors in metazoans and cyclic AMP in Dictyostelium, activate signaling pathways that control organization of the actin cytoskeleton and...
4.
Newell-Litwa K, Badoual M, Asmussen H, Patel H, Whitmore L, Horwitz A
J Cell Biol
. 2015 Jul;
210(2):225-42.
PMID: 26169356
RhoGTPases organize the actin cytoskeleton to generate diverse polarities, from front-back polarity in migrating cells to dendritic spine morphology in neurons. For example, RhoA through its effector kinase, RhoA kinase...
5.
Juanes-Garcia A, Chapman J, Aguilar-Cuenca R, Delgado-Arevalo C, Hodges J, Whitmore L, et al.
J Cell Biol
. 2015 Apr;
209(1):23-32.
PMID: 25869664
In this study, we show that the role of nonmuscle myosin II (NMII)-B in front-back migratory cell polarity is controlled by a short stretch of amino acids containing five serines...
6.
Hodges J, Martin Vilchez S, Asmussen H, Whitmore L, Horwitz A
PLoS One
. 2014 Jul;
9(7):e101770.
PMID: 25007055
Dendritic spines are micron-sized protrusions that constitute the primary post-synaptic sites of excitatory neurotransmission in the brain. Spines mature from a filopodia-like protrusion into a mushroom-shaped morphology with a post-synaptic...
7.
Potvin-Trottier L, Chen L, Horwitz A, Wiseman P
New J Phys
. 2013 Nov;
15.
PMID: 24223019
We introduce a new generalized theoretical framework for image correlation spectroscopy (ICS). Using this framework, we extend the ICS method in time-frequency (, nu) space to map molecular flow of...
8.
Tejera E, Rocha-Perugini V, Lopez-Martin S, Perez-Hernandez D, Bachir A, Horwitz A, et al.
Mol Biol Cell
. 2012 Dec;
24(3):261-73.
PMID: 23264468
CD81 is a member of the tetraspanin family that has been described to have a key role in cell migration of tumor and immune cells. To unravel the mechanisms of...
9.
Horwitz A
Nat Rev Mol Cell Biol
. 2012 Nov;
13(12):805-11.
PMID: 23151664
Recognition of the importance of cell adhesion grew steadily during the twentieth century as it promised answers to fundamental questions in diverse fields that included cell biology, developmental biology, tumorigenesis,...
10.
Toplak T, Pandzic E, Chen L, Vicente-Manzanares M, Horwitz A, Wiseman P
Biophys J
. 2012 Oct;
103(8):1672-82.
PMID: 23083710
Two-color spatio-temporal image cross-correlation spectroscopy (STICCS) is a new, to our knowledge, image analysis method that calculates space-time autocorrelation and cross-correlation functions from fluorescence intensity fluctuations. STICCS generates cellular flow...