Alan F Horwitz
Overview
Explore the profile of Alan F Horwitz including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
35
Citations
2788
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migration
Lagarrigue F, Anekal P, Lee H, Bachir A, Ablack J, Horwitz A, et al.
Nat Commun
. 2015 Oct;
6:8492.
PMID: 26419705
The leading edge of migrating cells contains rapidly translocating activated integrins associated with growing actin filaments that form 'sticky fingers' to sense extracellular matrix and guide cell migration. Here we...
2.
Lamers M, Almeida M, Vicente-Manzanares M, Horwitz A, Santos M
PLoS One
. 2011 Aug;
6(8):e22865.
PMID: 21826213
Deficient wound healing in diabetic patients is very frequent, but the cellular and molecular causes are poorly defined. In this study, we evaluate the hypothesis that high glucose concentrations inhibit...
3.
Cirit M, Krajcovic M, Choi C, Welf E, Horwitz A, Haugh J
PLoS Comput Biol
. 2010 Mar;
6(2):e1000688.
PMID: 20195494
Productive cell migration requires the spatiotemporal coordination of cell adhesion, membrane protrusion, and actomyosin-mediated contraction. Integrins, engaged by the extracellular matrix (ECM), nucleate the formation of adhesive contacts at the...
4.
Hall E, Daugherty A, Choi C, Horwitz A, Brautigan D
J Biol Chem
. 2009 Oct;
284(50):34713-22.
PMID: 19826001
Tensin is a family of multidomain scaffold proteins that bind the cytoplasmic tail of beta-integrins and localize to adhesions that anchor stress fibers in cells. Tensin expression is suppressed in...
5.
Pfister A, Zhang G, Zareno J, Horwitz A, Fraser C
ACS Nano
. 2008 Dec;
2(6):1252-8.
PMID: 19081748
Difluoroboron dibenzoylmethane-polylactide, BF(2)dbmPLA, a biocompatible polymer-luminophore conjugate was fabricated as nanoparticles. Spherical particles <100 nm in size were generated via nanoprecipitation. Intense blue fluorescence, two-photon absorption, and long-lived room temperature...
6.
Vicente-Manzanares M, Koach M, Whitmore L, Lamers M, Horwitz A
J Cell Biol
. 2008 Oct;
183(3):543-54.
PMID: 18955554
We have found that MLC-dependent activation of myosin IIB in migrating cells is required to form an extended rear, which coincides with increased directional migration. Activated myosin IIB localizes prominently...
7.
Easley 4th C, Brown C, Horwitz A, Tombes R
Cell Motil Cytoskeleton
. 2008 Jul;
65(8):662-74.
PMID: 18613116
Transient elevations in Ca2+ have previously been shown to promote focal adhesion disassembly and cell motility through an unknown mechanism. In this study, evidence is provided to show that CaMK-II,...
8.
Murase S, Cho C, White J, Horwitz A
Eur J Neurosci
. 2008 Apr;
27(7):1585-95.
PMID: 18380661
Neuroblasts migrate from the subventricular zone along the rostral migratory stream (RMS) to the olfactory bulb (OB). While the migration occurs by movement over other cells, the molecular mechanisms are...
9.
Digman M, Dalal R, Horwitz A, Gratton E
Biophys J
. 2007 Dec;
94(6):2320-32.
PMID: 18096627
We describe a technique based on moment-analysis for the measurement of the average number of molecules and brightness in each pixel in fluorescence microscopy images. The average brightness of the...
10.
Owen K, Pixley F, Thomas K, Vicente-Manzanares M, Ray B, Horwitz A, et al.
J Cell Biol
. 2007 Dec;
179(6):1275-87.
PMID: 18070912
Macrophages are a key component of the innate immune system. In this study, we investigate how focal adhesion kinase (FAK) and the related kinase Pyk2 integrate adhesion signaling and growth...