Leandro Cerchietti
Overview
Explore the profile of Leandro Cerchietti including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
89
Citations
4158
Followers
0
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Recent Articles
1.
Rivera-Correa J, Gupta S, Ricker E, Flores-Castro D, Jenkins D, Vulcano S, et al.
JCI Insight
. 2025 Feb;
10(5).
PMID: 39903532
The mechanisms utilized by differentiating B cells to withstand highly damaging conditions generated during severe infections, like the massive hemolysis that accompanies malaria, are poorly understood. Here, we demonstrate that...
2.
Maity D, Sivakumar N, Kamat P, Zamponi N, Min C, Du W, et al.
Adv Sci (Weinh)
. 2024 Aug;
11(38):e2400918.
PMID: 39136147
Cell motility plays an essential role in many biological processes as cells move and interact within their local microenvironments. Current methods for quantifying cell motility typically involve tracking individual cells...
3.
Cancila V, Morello G, Bertolazzi G, Chan A, Bastianello G, Paysan D, et al.
Res Sq
. 2024 Apr;
PMID: 38562878
The germinal center (GC) dark zone (DZ) and light zone (LZ) regions spatially separate expansion and diversification from selection of antigen-specific B-cells to ensure antibody affinity maturation and B cell...
4.
Cerchietti L
Blood
. 2024 Jan;
143(12):1101-1111.
PMID: 38211334
Cells in the tumor microenvironment (TME) of diffuse large B-cell lymphoma (DLBCL) show enormous diversity and plasticity, with functions that can range from tumor inhibitory to tumor supportive. The patient's...
5.
Marullo R, Rutherford S, Revuelta M, Zamponi N, Culjkovic-Kraljacic B, Kotlov N, et al.
Cancer Res
. 2023 Oct;
84(1):101-117.
PMID: 37801604
Significance: XPO1 regulates the dynamic ribonucleoprotein nuclear export in response to genotoxic stress to support tolerance and can be targeted to enhance the sensitivity of cancer cells to endogenous and...
6.
Larrayoz M, Garcia-Barchino M, Celay J, Etxebeste A, Jimenez M, Perez C, et al.
Nat Med
. 2023 Mar;
29(3):632-645.
PMID: 36928817
The historical lack of preclinical models reflecting the genetic heterogeneity of multiple myeloma (MM) hampers the advance of therapeutic discoveries. To circumvent this limitation, we screened mice engineered to carry...
7.
Ghram M, Morris G, Culjkovic-Kraljacic B, Mars J, Gendron P, Skrabanek L, et al.
EMBO J
. 2023 Feb;
42(7):e110496.
PMID: 36843541
Aberrant splicing is typically attributed to splice-factor (SF) mutation and contributes to malignancies including acute myeloid leukemia (AML). Here, we discovered a mutation-independent means to extensively reprogram alternative splicing (AS)....
8.
Ruan J, Moskowitz A, Mehta-Shah N, Sokol L, Chen Z, Kotlov N, et al.
Blood
. 2023 Feb;
141(18):2194-2205.
PMID: 36796016
Peripheral T-cell lymphomas (PTCL) with T-follicular helper phenotype (PTCL-TFH) has recurrent mutations affecting epigenetic regulators, which may contribute to aberrant DNA methylation and chemoresistance. This phase 2 study evaluated oral...
9.
Cappelli L, Fiore D, Phillip J, Yoffe L, Di Giacomo F, Chiu W, et al.
Blood
. 2022 Aug;
141(5):503-518.
PMID: 35981563
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive and often incurable disease. To uncover therapeutic vulnerabilities, we first developed T-ALL patient-derived tumor xenografts (PDXs) and exposed PDX cells to a...
10.
Zaitsev A, Chelushkin M, Dyikanov D, Cheremushkin I, Shpak B, Nomie K, et al.
Cancer Cell
. 2022 Aug;
40(8):879-894.e16.
PMID: 35944503
Cellular deconvolution algorithms virtually reconstruct tissue composition by analyzing the gene expression of complex tissues. We present the decision tree machine learning algorithm, Kassandra, trained on a broad collection of...