Lea G Hansen
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Explore the profile of Lea G Hansen including associated specialties, affiliations and a list of published articles.
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6
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105
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Recent Articles
1.
Holtz M, Rago D, Nedermark I, Hansson F, Lehka B, Hansen L, et al.
Metab Eng
. 2024 Oct;
86:135-146.
PMID: 39366478
Monoterpene indole alkaloids (MIAs) from Mitragyna speciosa ("kratom"), such as mitragynine and speciogynine, are promising novel scaffolds for opioid receptor ligands for treatment of pain, addiction, and depression. While kratom...
2.
Bradley S, Hansson F, Lehka B, Rago D, Pinho P, Peng H, et al.
ACS Synth Biol
. 2024 Apr;
13(5):1498-1512.
PMID: 38635307
Monoterpene indole alkaloids (MIAs) make up a highly bioactive class of metabolites produced by a range of tropical and subtropical plants. The corynanthe-type MIAs are a stereochemically complex subclass with...
3.
Petersen S, Levassor L, Pedersen C, Madsen J, Hansen L, Zhang J, et al.
PLoS Comput Biol
. 2024 Mar;
20(3):e1011929.
PMID: 38457467
Synthetic biology dictates the data-driven engineering of biocatalysis, cellular functions, and organism behavior. Integral to synthetic biology is the aspiration to efficiently find, access, interoperate, and reuse high-quality data on...
4.
Bradley S, Lehka B, Hansson F, Adhikari K, Rago D, Rubaszka P, et al.
Nat Chem Biol
. 2023 Nov;
19(12):1551-1560.
PMID: 37932529
Monoterpenoid indole alkaloids (MIAs) represent a large class of plant natural products with marketed pharmaceutical activities against a wide range of indications, including cancer, malaria and hypertension. Halogenated MIAs have...
5.
Zhang J, Hansen L, Gudich O, Viehrig K, Lassen L, Schrubbers L, et al.
Nature
. 2022 Aug;
609(7926):341-347.
PMID: 36045295
Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary metabolites with many medicinal properties, including the essential anti-cancer therapeutics vinblastine and vincristine. As MIAs are difficult to...
6.
DAmbrosio V, Hansen L, Zhang J, Jensen E, Arsovska D, Laloux M, et al.
Synth Syst Biotechnol
. 2022 Feb;
7(2):657-663.
PMID: 35224233
The synthetic biology toolkit for baker's yeast, , includes extensive genome engineering toolkits and parts repositories. However, with the increasing complexity of engineering tasks and versatile applications of this model...