Jay D Keasling
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Explore the profile of Jay D Keasling including associated specialties, affiliations and a list of published articles.
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465
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17440
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Recent Articles
1.
Zhan C, Lan G, Dan Q, Qin N, Pearson A, Mellinger P, et al.
Metab Eng
. 2025 Mar;
PMID: 40057262
Converting polyethylene (PE) into valuable materials, particularly ones that are better for the environment than the incumbent plastics, not only helps mitigate environmental issues caused by plastic waste but also...
2.
Carruthers D, Donnell I, Sundstrom E, Keasling J, Lee T
Metab Eng
. 2025 Jan;
88:261-274.
PMID: 39870203
Prenol and isoprenol are promising advanced biofuels and serve as biosynthetic precursors for pharmaceuticals, fragrances, and other industrially relevant compounds. Despite engineering improvements that circumvent intermediate cytotoxicity and lower energy...
3.
He D, Chen Y, Shen J, Yu H, Keasling J, Luo X
Metab Eng
. 2025 Jan;
88:240-249.
PMID: 39842502
10-hydroxy-2-decenoic acid (10-HDA), a unique unsaturated fatty acid present in royal jelly, has attracted considerable interest due to its potential medical applications. However, its low concentration in royal jelly and...
4.
Szarzanowicz M, Waldburger L, Busche M, Geiselman G, Kirkpatrick L, Kehl A, et al.
Nat Biotechnol
. 2024 Nov;
PMID: 39496930
The copy number of a plasmid is linked to its functionality, yet there have been few attempts to optimize higher-copy-number mutants for use across diverse origins of replication in different...
5.
Holtz M, Rago D, Nedermark I, Hansson F, Lehka B, Hansen L, et al.
Metab Eng
. 2024 Oct;
86:135-146.
PMID: 39366478
Monoterpene indole alkaloids (MIAs) from Mitragyna speciosa ("kratom"), such as mitragynine and speciogynine, are promising novel scaffolds for opioid receptor ligands for treatment of pain, addiction, and depression. While kratom...
6.
Maini Rekdal V, Villalobos-Escobedo J, Rodriguez-Valeron N, Olaizola Garcia M, Vasquez D, Rosales A, et al.
Nat Microbiol
. 2024 Aug;
9(10):2666-2683.
PMID: 39209985
Fungal fermentation of food and agricultural by-products holds promise for improving food sustainability and security. However, the molecular basis of fungal waste-to-food upcycling remains poorly understood. Here we use a...
7.
A Simple and Effective Strategy for the Development of Robust Promoter-Centric Gene Expression Tools
Yang T, Chen Y, Luo X, Keasling J, Fan K, Pan G
ACS Synth Biol
. 2024 Aug;
13(9):2780-2790.
PMID: 39120429
Promoter-centric genetic tools play a crucial role in controlling gene expression for various applications, such as strain engineering and synthetic biology studies. Hence, a critical need persists for the development...
8.
Winegar P, Hudson G, Dell L, Astolfi M, Reed J, Payet R, et al.
Metab Eng
. 2024 Jul;
85:145-158.
PMID: 39074544
Steroidal alkaloids are FDA-approved drugs (e.g., Zytiga) and promising drug candidates/leads (e.g., cyclopamine); yet many of the ≥697 known steroidal alkaloid natural products remain underutilized as drugs because it can...
9.
Yunus I, Hudson G, Chen Y, Gin J, Kim J, Baidoo E, et al.
Metab Eng
. 2024 Jun;
84:69-82.
PMID: 38839037
Sunscreen has been used for thousands of years to protect skin from ultraviolet radiation. However, the use of modern commercial sunscreen containing oxybenzone, ZnO, and TiO has raised concerns due...
10.
Crowe S, Liu Y, Zhao X, Scheller H, Keasling J
ACS Synth Biol
. 2024 May;
13(6):1589-1599.
PMID: 38820348
Glycosylation is a ubiquitous modification present across all of biology, affecting many things such as physicochemical properties, cellular recognition, subcellular localization, and immunogenicity. Nucleotide sugars are important precursors needed to...