Lawrence Yoon
Overview
Explore the profile of Lawrence Yoon including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
211
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Recent Articles
1.
Stokes A, Falls J, Yoon L, Cariello N, Faiola B, Colton H, et al.
Int J Toxicol
. 2015 Feb;
34(2):151-61.
PMID: 25722321
Cardiovascular (CV) safety concerns are among the leading causes of compound attrition in drug development. This work describes a strategy of applying novel end points to a 7-day rodent study...
2.
Cianciolo R, Yoon L, Krull D, Stokes A, Rodriguez A, Jordan H, et al.
Nephron Exp Nephrol
. 2013 Nov;
124(1-2):1-10.
PMID: 24248038
Background: Tubular atrophy and interstitial fibrosis are well-recognized sequelae of chronic proteinuria; however, little is known regarding the molecular pathways activated within tubulointerstitium in chronic proteinuric nephropathies. Methods: To investigate...
3.
Slocum N, Durrant J, Bailey D, Yoon L, Jordan H, Barton J, et al.
Exp Toxicol Pathol
. 2012 May;
65(5):549-57.
PMID: 22542811
Drug-induced weight loss in humans has been associated with undesirable side effects not present in weight loss from lifestyle interventions (caloric restriction or exercise). To investigate the mechanistic differences of...
4.
Crosby L, Casey W, Morgan K, Ni H, Yoon L, Easton M, et al.
Nitric Oxide
. 2010 Jan;
22(3):242-57.
PMID: 20097302
Specific bacterial lipopolysaccharides (LPS), IFN-gamma, and unmethylated cytosine or guanosine-phosphorothioate containing DNAs (CpG) activate host immunity, influencing infectious responses. Macrophages detect, inactivate and destroy infectious particles, and synthetic CpG sequences...
5.
Cariello N, Romach E, Colton H, Ni H, Yoon L, Falls J, et al.
Toxicol Sci
. 2005 Aug;
88(1):250-64.
PMID: 16081524
Fibrates, such as ciprofibrate, fenofibrate, and clofibrate, are peroxisome proliferator-activated receptor-alpha (PPARalpha) agonists that have been in clinical use for many decades for treatment of dyslipidemia. When mice and rats...
6.
Anderson S, Dunn C, Laughter A, Yoon L, Swanson C, Stulnig T, et al.
Mol Pharmacol
. 2004 Sep;
66(6):1440-52.
PMID: 15371561
Lipid homeostasis is controlled in part by the nuclear receptors peroxisome proliferator (PP)-activated receptor alpha (PPARalpha) and liver X receptor (LXR) through regulation of genes involved in fatty acid and...
7.
Corton J, Apte U, Anderson S, Limaye P, Yoon L, Latendresse J, et al.
J Biol Chem
. 2004 Aug;
279(44):46204-12.
PMID: 15302862
The obesity epidemic in industrialized countries is associated with increases in cardiovascular disease (CVD) and certain types of cancer. In animal models, caloric restriction (CR) suppresses these diseases as well...
8.
Morgan K, Casey W, Easton M, Creech D, Ni H, Yoon L, et al.
Toxicol Pathol
. 2003 Jul;
31(4):448-61.
PMID: 12851109
Cultured cell lines are employed extensively for biological research. Large-scale differential gene expression (LSDGE) is being used to study mechanisms of toxicity in such cultures. 'Normal' gene expression dynamics could...
9.
Hester S, Benavides G, Yoon L, Morgan K, Zou F, Barry W, et al.
Toxicology
. 2003 Apr;
187(1):13-24.
PMID: 12679049
Formaldehyde (FA), an occupational and environmental toxicant used extensively in the manufacturing of many household and personal use products, is known to induce squamous cell carcinomas in the nasal turbinates...
10.
Anderson S, Yoon L, Richard E, Dunn C, Cattley R, Corton J
Hepatology
. 2002 Aug;
36(3):544-54.
PMID: 12198646
Peroxisome proliferator chemicals, acting via the peroxisome proliferator-activated receptor-alpha (Pparalpha), are potent hepatic mitogens and carcinogens in mice and rats. To test whether Pparalpha is required for hepatic growth in...