Lawrence H Young
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Explore the profile of Lawrence H Young including associated specialties, affiliations and a list of published articles.
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104
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Recent Articles
1.
Goedeke L, Ma Y, Gaspar R, Nasiri A, Lee J, Zhang D, et al.
J Clin Invest
. 2024 Dec;
134(24).
PMID: 39680452
Previous studies highlight the potential for sodium-glucose cotransporter type 2 (SGLT2) inhibitors (SGLT2i) to exert cardioprotective effects in heart failure by increasing plasma ketones and shifting myocardial fuel utilization toward...
2.
Douglas T, Zhang J, Wu Z, Abdallah K, McReynolds M, Gilbert W, et al.
bioRxiv
. 2024 Oct;
PMID: 39416039
Metabolic stress must be effectively mitigated for the survival of cells and organisms. Ribosomes have emerged as signaling hubs that sense metabolic perturbations and coordinate responses that either restore homeostasis...
3.
Toksoy Z, Ma Y, Goedeke L, Li W, Hu X, Wu X, et al.
bioRxiv
. 2024 Sep;
PMID: 39257756
Atrial fibrillation is the most common clinical arrhythmia and may be due in part to metabolic stress. Atrial specific deletion of the master metabolic sensor, AMP-activated protein kinase (AMPK), induces...
4.
Huang Y, Gao P, Young L, Qi D
Trends Pharmacol Sci
. 2024 Jul;
45(10):868-871.
PMID: 39054181
Metabolic and endocrine dysfunction of white adipose tissue (WAT) is linked to inflammation, which has been considered a key mechanism of insulin resistance (IR). However, recent studies revealed non-inflammatory mechanisms...
5.
Rudokas M, McKay M, Toksoy Z, Eisen J, Bogner M, Young L, et al.
Cardiovasc Diabetol
. 2024 Jul;
23(1):261.
PMID: 39026280
Mitochondria play a central role in cellular energy metabolism, and their dysfunction is increasingly recognized as a critical factor in the pathogenesis of diabetes-related cardiac pathophysiology, including vulnerability to ischemic...
6.
Huang Y, Chen L, Li L, Qi Y, Tong H, Wu H, et al.
JCI Insight
. 2024 Jul;
9(13).
PMID: 38973609
Lipoprotein lipase (LPL) hydrolyzes circulating triglycerides (TGs), releasing fatty acids (FA) and promoting lipid storage in white adipose tissue (WAT). However, the mechanisms regulating adipose LPL and its relationship with...
7.
Griffin M, Odanovic N, McNamara R, Altin S, Balan S, Thompson J, et al.
CASE (Phila)
. 2024 Jan;
7(12):502-507.
PMID: 38197115
No abstract available.
8.
Hsu I, Lin Y, Guo Y, Xu Q, Shao Y, Wang R, et al.
bioRxiv
. 2024 Jan;
PMID: 38168446
The organ-intrinsic nervous system is a major interface between visceral organs and the brain, mediating important sensory and regulatory functions in the body-brain axis and serving as critical local processors...
9.
Oikonomou E, Thangaraj P, Bhatt D, Ross J, Young L, Krumholz H, et al.
NPJ Digit Med
. 2023 Nov;
6(1):217.
PMID: 38001154
Randomized clinical trials (RCT) represent the cornerstone of evidence-based medicine but are resource-intensive. We propose and evaluate a machine learning (ML) strategy of adaptive predictive enrichment through computational trial phenomaps...
10.
Oikonomou E, Thangaraj P, Bhatt D, Ross J, Young L, Krumholz H, et al.
medRxiv
. 2023 Nov;
PMID: 37961715
Randomized controlled trials (RCT) represent the cornerstone of evidence-based medicine but are resource-intensive. We propose and evaluate a machine learning (ML) strategy of adaptive predictive enrichment through computational trial phenomaps...