Laurent Delpy
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Explore the profile of Laurent Delpy including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
693
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Recent Articles
11.
Ashi M, Srour N, Lambert J, Marchalot A, Martin O, Le Noir S, et al.
Cell Mol Immunol
. 2018 Aug;
16(10):810-819.
PMID: 30127381
The error-prone V(D)J recombination process generates considerable amounts of nonproductive immunoglobulin (Ig) pre-mRNAs. We recently demonstrated that aberrant Ig chains lacking variable (V) domains can be produced after nonsense-associated altered...
12.
Srour N, Chemin G, Tinguely A, Ashi M, Oruc Z, Peron S, et al.
J Exp Med
. 2015 Dec;
213(1):109-22.
PMID: 26666261
Aberrantly rearranged immunoglobulin (Ig) alleles are frequent. They are usually considered sterile and innocuous as a result of nonsense-mediated mRNA decay. However, alternative splicing can yield internally deleted proteins from...
13.
Bonaud A, Bender S, Touchard G, Lacombe C, Srour N, Delpy L, et al.
Blood
. 2015 Jun;
126(6):757-65.
PMID: 26113545
Randall-type heavy chain deposition disease (HCDD) is a rare disorder characterized by glomerular and peritubular amorphous deposits of a truncated monoclonal immunoglobulin heavy chain (HC) bearing a deletion of the...
14.
Lechouane F, Bonaud A, Delpy L, Casola S, Oruc Z, Chemin G, et al.
Eur J Immunol
. 2013 Jan;
43(3):619-28.
PMID: 23280426
B-cell terminal differentiation into antibody secreting plasma cells (PCs) features a transcriptional shift driven by the activation of plasma cell lineage determinants such as Blimp-1 and Xbp-1, together with the...
15.
Saada S, Marget P, Fauchais A, Lise M, Chemin G, Sindou P, et al.
J Immunol
. 2012 Oct;
189(11):5293-303.
PMID: 23109725
Neurotensin, a neuropeptide growth factor, and its two specific neurotensin receptors, NTSR1 and NTSR2, were shown to be expressed by human B cell lines. Another NTSR, sortilin, which is common...
16.
Peron S, Laffleur B, Denis-Lagache N, Cook-Moreau J, Tinguely A, Delpy L, et al.
Science
. 2012 Apr;
336(6083):931-4.
PMID: 22539552
Remodeling of immunoglobulin genes by activation-induced deaminase (AID) is required for affinity maturation and class-switch recombination in mature B lymphocytes. In the immunoglobulin heavy chain locus, these processes are predominantly...
17.
Tinguely A, Chemin G, Peron S, Sirac C, Reynaud S, Cogne M, et al.
Mol Cell Biol
. 2011 Nov;
32(1):107-17.
PMID: 22037763
Immunoglobulin (Ig) genes naturally acquire frequent premature termination codons during the error-prone V(D)J recombination process. Although B cell differentiation is linked to the expression of productive Ig alleles, the transcriptional...
18.
Lelu K, Laffont S, Delpy L, Paulet P, Perinat T, Tschanz S, et al.
J Immunol
. 2011 Aug;
187(5):2386-93.
PMID: 21810607
Estrogen treatment exerts a protective effect on experimental autoimmune encephalomyelitis (EAE) and is under clinical trial for multiple sclerosis therapy. Estrogens have been suspected to protect from CNS autoimmunity through...
19.
Lelu K, Delpy L, Robert V, Foulon E, Laffont S, Pelletier L, et al.
Eur J Immunol
. 2010 Nov;
40(12):3489-98.
PMID: 21108469
Sex hormones influence immune responses and the development of autoimmune diseases including MS and its animal model, EAE. Although it has been previously reported that ovariectomy could worsen EAE, the...
20.
Savignac M, Mellstrom B, Bebin A, Oliveros J, Delpy L, Pinaud E, et al.
J Immunol
. 2010 Nov;
185(12):7527-36.
PMID: 21059893
DREAM/KChIP-3 is a calcium-dependent transcriptional repressor highly expressed in immune cells. Transgenic mice expressing a dominant active DREAM mutant show reduced serum Ig levels. In vitro assays show that reduced...