Laurent Delpy
Overview
Explore the profile of Laurent Delpy including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
693
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Recent Articles
21.
Calippe B, Douin-Echinard V, Delpy L, Laffargue M, Lelu K, Krust A, et al.
J Immunol
. 2010 Jun;
185(2):1169-76.
PMID: 20554954
17Beta-estradiol (E2) has been shown to promote the expression of inflammatory mediators by LPS-activated tissue resident macrophages through estrogen receptor alpha (ERalpha) signaling. However, it remained to be determined whether...
22.
Chemin G, Tinguely A, Sirac C, Lechouane F, Duchez S, Cogne M, et al.
J Immunol
. 2010 Apr;
184(9):5009-17.
PMID: 20357261
Random V(D)J junctions ensure that the diversity of the Ig primary repertoire is adapted to the vast heterogeneity of Ags. In two-thirds of cases, recombination between variable segments induces a...
23.
Duchez S, Amin R, Cogne N, Delpy L, Sirac C, Pascal V, et al.
Proc Natl Acad Sci U S A
. 2010 Feb;
107(7):3064-9.
PMID: 20133609
Sequentially along B cell differentiation, the different classes of membrane Ig heavy chains associate with the Ig alpha/Ig beta heterodimer within the B cell receptor (BCR). Whether each Ig class...
24.
Billon-Gales A, Fontaine C, Douin-Echinard V, Delpy L, Berges H, Calippe B, et al.
Circulation
. 2009 Dec;
120(25):2567-76.
PMID: 19996016
Background: The prevention of early atheroma by estrogens has been clearly demonstrated in all animal models and appears to be mediated through a direct action on the arterial wall rather...
25.
Douin-Echinard V, Laffont S, Seillet C, Delpy L, Krust A, Chambon P, et al.
J Immunol
. 2008 Mar;
180(6):3661-9.
PMID: 18322171
Dendritic cells (DC) are critical actors in the initiation of primary immune responses and regulation of self-tolerance. The steroid sex hormone 17beta-estradiol (E(2)) has been shown to promote the differentiation...
26.
Dougier H, Reynaud S, Pinaud E, Carrion C, Delpy L, Cogne M
Eur J Immunol
. 2006 Jul;
36(8):2181-91.
PMID: 16874738
The predominant path of immunoglobulin class switch recombination follows the paradigm of intra-chromosomal deletion enabling expression of another heavy chain instead of micro and delta. This was, however, challenged by...
27.
Laffont S, Coudert J, Garidou L, Delpy L, Wiedemann A, Demur C, et al.
Blood
. 2006 Feb;
108(7):2257-64.
PMID: 16449531
Accumulating evidence indicates that, in absence of CD8+ T-cell activation, CD4+ T-cell-mediated allograft rejection is associated with a dominant Th2-cell response and eosinophil infiltrates. In this study, we analyzed the...
28.
Delpy L, Douin-Echinard V, Garidou L, Bruand C, Saoudi A, Guery J
J Immunol
. 2005 Oct;
175(8):5050-7.
PMID: 16210608
Myasthenia gravis (MG) is an organ-specific autoimmune disease caused in most cases by autoantibodies against the nicotinic acetylcholine receptor (AChR). It is now well documented that many autoimmune diseases, including...
29.
Reynaud S, Delpy L, Fleury L, Dougier H, Sirac C, Cogne M
J Immunol
. 2005 May;
174(10):6176-83.
PMID: 15879114
Except for the expression of IgM and IgD, DNA recombination is constantly needed for the expression of other Ig classes and subclasses. The predominant path of class switch recombination (CSR)...
30.
Delpy L, Sirac C, Le Morvan C, Cogne M
J Immunol
. 2004 Jul;
173(3):1842-8.
PMID: 15265916
Allelic exclusion of IgH chain expression is stringently established before or during early B cell maturation. It likely relies both on cellular mechanisms, selecting those cells in which a single...