Aurelien Tinguely
Overview
Explore the profile of Aurelien Tinguely including associated specialties, affiliations and a list of published articles.
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4
Citations
97
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Recent Articles
1.
Srour N, Chemin G, Tinguely A, Ashi M, Oruc Z, Peron S, et al.
J Exp Med
. 2015 Dec;
213(1):109-22.
PMID: 26666261
Aberrantly rearranged immunoglobulin (Ig) alleles are frequent. They are usually considered sterile and innocuous as a result of nonsense-mediated mRNA decay. However, alternative splicing can yield internally deleted proteins from...
2.
Peron S, Laffleur B, Denis-Lagache N, Cook-Moreau J, Tinguely A, Delpy L, et al.
Science
. 2012 Apr;
336(6083):931-4.
PMID: 22539552
Remodeling of immunoglobulin genes by activation-induced deaminase (AID) is required for affinity maturation and class-switch recombination in mature B lymphocytes. In the immunoglobulin heavy chain locus, these processes are predominantly...
3.
Tinguely A, Chemin G, Peron S, Sirac C, Reynaud S, Cogne M, et al.
Mol Cell Biol
. 2011 Nov;
32(1):107-17.
PMID: 22037763
Immunoglobulin (Ig) genes naturally acquire frequent premature termination codons during the error-prone V(D)J recombination process. Although B cell differentiation is linked to the expression of productive Ig alleles, the transcriptional...
4.
Chemin G, Tinguely A, Sirac C, Lechouane F, Duchez S, Cogne M, et al.
J Immunol
. 2010 Apr;
184(9):5009-17.
PMID: 20357261
Random V(D)J junctions ensure that the diversity of the Ig primary repertoire is adapted to the vast heterogeneity of Ags. In two-thirds of cases, recombination between variable segments induces a...