Lauren LeBon
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Explore the profile of Lauren LeBon including associated specialties, affiliations and a list of published articles.
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9
Citations
734
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Recent Articles
1.
Labbe K, LeBon L, King B, Vu N, Stoops E, Ly N, et al.
Nat Commun
. 2024 Sep;
15(1):8301.
PMID: 39333061
The integrated stress response (ISR) enables cells to cope with a variety of insults, but its specific contribution to downstream cellular outputs remains unclear. Using a synthetic tool, we selectively...
2.
Asundi J, Zhang C, Donnelly-Roberts D, Solorio J, Challagundla M, Connelly C, et al.
CNS Neurosci Ther
. 2024 Feb;
30(2):e14600.
PMID: 38357857
Aim: Characterize Growth Differentiation Factor 15 (GDF15) as a secreted biomarker of the integrated stress response (ISR) within the central nervous system (CNS). Methods: We determined GDF15 levels utilizing in ...
3.
Hao Q, Heo J, Nocek B, Hicks K, Stoll V, Remarcik C, et al.
Nat Commun
. 2021 Jun;
12(1):3440.
PMID: 34103529
The multi-subunit translation initiation factor eIF2B is a control node for protein synthesis. eIF2B activity is canonically modulated through stress-responsive phosphorylation of its substrate eIF2. The eIF2B regulatory subcomplex is...
4.
Liang Wong Y, LeBon L, Basso A, Kohlhaas K, Nikkel A, Robb H, et al.
Elife
. 2019 Jan;
8.
PMID: 30624206
The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to...
5.
Liang Wong Y, LeBon L, Edalji R, Lim H, Sun C, Sidrauski C
Elife
. 2018 Mar;
7.
PMID: 29489452
eIF2B is a dedicated guanine nucleotide exchange factor for eIF2, the GTPase that is essential to initiate mRNA translation. The integrated stress response (ISR) signaling pathway inhibits eIF2B activity, attenuates...
6.
Nandagopal N, Santat L, LeBon L, Sprinzak D, Bronner M, Elowitz M
Cell
. 2018 Feb;
172(4):869-880.e19.
PMID: 29398116
The Notch signaling pathway comprises multiple ligands that are used in distinct biological contexts. In principle, different ligands could activate distinct target programs in signal-receiving cells, but it is unclear...
7.
LeBon L, Lee T, Sprinzak D, Jafar-Nejad H, Elowitz M
Elife
. 2014 Sep;
3:e02950.
PMID: 25255098
The Notch signaling pathway consists of multiple types of receptors and ligands, whose interactions can be tuned by Fringe glycosyltransferases. A major challenge is to determine how these components control...
8.
Sprinzak D, Lakhanpal A, LeBon L, Garcia-Ojalvo J, Elowitz M
PLoS Comput Biol
. 2011 Jun;
7(6):e1002069.
PMID: 21695234
Developmental patterning requires juxtacrine signaling in order to tightly coordinate the fates of neighboring cells. Recent work has shown that Notch and Delta, the canonical metazoan juxtacrine signaling receptor and...
9.
Sprinzak D, Lakhanpal A, LeBon L, Santat L, Fontes M, Anderson G, et al.
Nature
. 2010 Apr;
465(7294):86-90.
PMID: 20418862
The Notch-Delta signalling pathway allows communication between neighbouring cells during development. It has a critical role in the formation of 'fine-grained' patterns, generating distinct cell fates among groups of initially...