Carmela Sidrauski
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Explore the profile of Carmela Sidrauski including associated specialties, affiliations and a list of published articles.
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15
Citations
1265
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Recent Articles
1.
Labbe K, LeBon L, King B, Vu N, Stoops E, Ly N, et al.
Nat Commun
. 2024 Sep;
15(1):8301.
PMID: 39333061
The integrated stress response (ISR) enables cells to cope with a variety of insults, but its specific contribution to downstream cellular outputs remains unclear. Using a synthetic tool, we selectively...
2.
Yan Y, Shetty M, Harding H, George G, Zyryanova A, Labbe K, et al.
Proc Natl Acad Sci U S A
. 2024 Mar;
121(14):e2320013121.
PMID: 38547060
Dephosphorylation of pSer51 of the α subunit of translation initiation factor 2 (eIF2α) terminates signaling in the integrated stress response (ISR). A trimeric mammalian holophosphatase comprised of a protein phosphatase...
3.
Asundi J, Zhang C, Donnelly-Roberts D, Solorio J, Challagundla M, Connelly C, et al.
CNS Neurosci Ther
. 2024 Feb;
30(2):e14600.
PMID: 38357857
Aim: Characterize Growth Differentiation Factor 15 (GDF15) as a secreted biomarker of the integrated stress response (ISR) within the central nervous system (CNS). Methods: We determined GDF15 levels utilizing in ...
4.
Maurano M, Snyder J, Connelly C, Henao-Mejia J, Sidrauski C, Stetson D
Immunity
. 2021 Aug;
54(9):1948-1960.e5.
PMID: 34343497
The RNA deaminase ADAR1 is an essential negative regulator of the RNA sensor MDA5, and loss of ADAR1 function triggers inappropriate activation of MDA5 by self-RNAs. Mutations in ADAR, the...
5.
Hao Q, Heo J, Nocek B, Hicks K, Stoll V, Remarcik C, et al.
Nat Commun
. 2021 Jun;
12(1):3440.
PMID: 34103529
The multi-subunit translation initiation factor eIF2B is a control node for protein synthesis. eIF2B activity is canonically modulated through stress-responsive phosphorylation of its substrate eIF2. The eIF2B regulatory subcomplex is...
6.
Liang Wong Y, LeBon L, Basso A, Kohlhaas K, Nikkel A, Robb H, et al.
Elife
. 2019 Jan;
8.
PMID: 30624206
The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to...
7.
Liang Wong Y, LeBon L, Edalji R, Lim H, Sun C, Sidrauski C
Elife
. 2018 Mar;
7.
PMID: 29489452
eIF2B is a dedicated guanine nucleotide exchange factor for eIF2, the GTPase that is essential to initiate mRNA translation. The integrated stress response (ISR) signaling pathway inhibits eIF2B activity, attenuates...
8.
Huang W, Placzek A, Di Prisco G, Khatiwada S, Sidrauski C, Krnjevic K, et al.
Elife
. 2016 Mar;
5.
PMID: 26928234
Adolescents are especially prone to drug addiction, but the underlying biological basis of their increased vulnerability remains unknown. We reveal that translational control by phosphorylation of the translation initiation factor...
9.
Placzek A, Molfese D, Khatiwada S, Di Prisco G, Huang W, Sidrauski C, et al.
Elife
. 2016 Mar;
5.
PMID: 26928076
Adolescents are particularly vulnerable to nicotine, the principal addictive component driving tobacco smoking. In a companion study, we found that reduced activity of the translation initiation factor eIF2α underlies the...
10.
Hearn B, Jaishankar P, Sidrauski C, Tsai J, Vedantham P, Fontaine S, et al.
ChemMedChem
. 2016 Jan;
11(8):870-80.
PMID: 26789650
The integrated stress response comprises multiple signaling pathways for detecting and responding to cellular stress that converge at a single event-the phosphorylation of Ser51 on the α-subunit of eukaryotic translation...