Laura M Bond
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Explore the profile of Laura M Bond including associated specialties, affiliations and a list of published articles.
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9
Citations
244
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Recent Articles
1.
Salazar-Villacorta A, Bond L, Kim L, Anagnostopoulou K, Scardamaglia A, Filippakopoulou E, et al.
medRxiv
. 2025 Feb;
PMID: 39974099
encodes fat-storage inducing transmembrane protein 2 (FIT2), a lipid diphosphatase in the ER that cleaves acyl-CoAs and is crucial for ER homeostasis. In humans, homozygous null mutations in are associated...
2.
Bond L, Ibrahim A, Lai Z, Walzem R, Bronson R, Ilkayeva O, et al.
J Biol Chem
. 2023 Feb;
299(3):103022.
PMID: 36805337
The endoplasmic reticulum (ER)-resident protein fat storage-inducing transmembrane protein 2 (FIT2) catalyzes acyl-CoA cleavage in vitro and is required for ER homeostasis and normal lipid storage in cells. The gene...
3.
Becuwe M, Bond L, Pinto A, Boland S, Mejhert N, Elliott S, et al.
J Cell Biol
. 2020 Sep;
219(10).
PMID: 32915949
The endoplasmic reticulum is a cellular hub of lipid metabolism, coordinating lipid synthesis with continuous changes in metabolic flux. Maintaining ER lipid homeostasis despite these fluctuations is crucial to cell...
4.
Piccolis M, Bond L, Kampmann M, Pulimeno P, Chitraju C, Jayson C, et al.
Mol Cell
. 2019 Mar;
74(1):32-44.e8.
PMID: 30846318
Excessive levels of saturated fatty acids are toxic to cells, although the basis for this lipotoxicity remains incompletely understood. Here, we analyzed the transcriptome, lipidome, and genetic interactions of human...
5.
Bond L, Burhans M, Ntambi J
PLoS One
. 2018 Nov;
13(11):e0205726.
PMID: 30427862
Inflammation and endoplasmic reticulum (ER) stress are hallmarks of metabolic syndrome. While these metabolic derangements have been well-investigated in white adipose tissue, their existence and etiology in brown adipose tissue...
6.
Bond L, Ntambi J
J Lipid Res
. 2017 Dec;
59(2):224-236.
PMID: 29203476
Uncoupling protein-1 (UCP1) facilitates thermogenesis in brown and beige adipocytes and can promote energy expenditure by decreasing mitochondrial respiratory efficiency. Defects in UCP1 and brown adipose tissue thermogenesis subject animals...
7.
Bond L, Skrobo D
BMJ Case Rep
. 2015 Oct;
2015.
PMID: 26443095
A 36-year-old woman presented to the emergency department with a 3-day history of an occipital headache associated with transient visual impairment and short-term memory loss. MRI of the brain showed...
8.
Marty A, Broman A, Zarnowski R, Dwyer T, Bond L, Lounes-Hadj Sahraoui A, et al.
PLoS Pathog
. 2015 Jun;
11(6):e1004959.
PMID: 26114571
In response to temperature, Blastomyces dermatitidis converts between yeast and mold forms. Knowledge of the mechanism(s) underlying this response to temperature remains limited. In B. dermatitidis, we identified a GATA...
9.
Burhans M, Flowers M, Harrington K, Bond L, Guo C, Anderson R, et al.
J Lipid Res
. 2015 Jan;
56(2):304-18.
PMID: 25555387
Hepatic steatosis is associated with detrimental metabolic phenotypes including enhanced risk for diabetes. Stearoyl-CoA desaturases (SCDs) catalyze the synthesis of MUFAs. In mice, genetic ablation of SCDs reduces hepatic de...
10.
Bond L, Peters J, Becker N, Kahn J, Maher 3rd L
Nucleic Acids Res
. 2010 Dec;
38(22):8072-82.
PMID: 21149272
The inflexibility of double-stranded DNA with respect to bending and twisting is well established in vitro. Understanding apparent DNA physical properties in vivo is a greater challenge. Here, we exploit...