Sebastian Boland
Overview
Explore the profile of Sebastian Boland including associated specialties, affiliations and a list of published articles.
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21
Citations
707
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Recent Articles
1.
Kennedy J, Vargas S, Fishman M, Alesi N, Baek S, Khabibillin D, et al.
Med
. 2025 Feb;
:100607.
PMID: 40020677
Background: Childhood interstitial and diffuse lung diseases are a collection of rare disorders with significant associated morbidity. Only a small subset of these diseases have precise diagnostic or therapeutic options...
2.
Byrd T, Boland S, Klem M, Silver D, Lu L, Neal M, et al.
J Surg Res
. 2025 Feb;
307:86-92.
PMID: 39999509
Introduction: The emergency colorectal surgery population represents one of the most vulnerable subsets of the larger emergency general surgery population, characterized by increased complication rates, mortality rates, health resource utilization,...
3.
Boland S, Lu L, Silver D, Byrd T, Guyette F, Brown J
J Trauma Acute Care Surg
. 2025 Feb;
PMID: 39998479
Background: Air medical transport (AMT) offers a survival advantage to trauma patients for several reasons, including time-savings over ground transport. Triage guidelines suggest AMT use when there are significant time-savings,...
4.
Beiriger J, Puyana J, Deeb A, Silver D, Lu L, Boland S, et al.
J Trauma Acute Care Surg
. 2024 Aug;
PMID: 39093636
Background: Trauma systems save lives by coordinating timely and effective responses to injury. However, trauma system effectiveness varies geographically, with worse outcomes observed in rural settings. Prior data suggest that...
5.
Sevigny J, Uspenskaya O, Heckman L, Wong L, Hatch D, Tewari A, et al.
Nat Med
. 2024 May;
30(5):1406-1415.
PMID: 38745011
GRN mutations cause progranulin haploinsufficiency, which eventually leads to frontotemporal dementia (FTD-GRN). PR006 is an investigational gene therapy delivering the granulin gene (GRN) using an adeno-associated virus serotype 9 (AAV9)...
6.
Wei J, Wong L, Boland S
Int J Mol Sci
. 2024 Jan;
25(1).
PMID: 38203300
Biomarkers are molecules that can be used to observe changes in an individual's biochemical or medical status and provide information to aid diagnosis or treatment decisions. Dysregulation in lipid metabolism...
7.
Ludzki A, Hansen M, Zareifi D, Jalkanen J, Huang Z, Omar-Hmeadi M, et al.
Sci Adv
. 2024 Jan;
10(1):eadi2689.
PMID: 38170777
Defects in adipocyte lipolysis drive multiple aspects of cardiometabolic disease, but the transcriptional framework controlling this process has not been established. To address this, we performed a targeted perturbation screen...
8.
Boland S, Swarup S, Ambaw Y, Malia P, Richards R, Fischer A, et al.
Nat Commun
. 2022 Oct;
13(1):5924.
PMID: 36207292
Haploinsufficiency of GRN causes frontotemporal dementia (FTD). The GRN locus produces progranulin (PGRN), which is cleaved to lysosomal granulin polypeptides. The function of lysosomal granulins and why their absence causes...
9.
Mejhert N, Gabriel K, Frendo-Cumbo S, Krahmer N, Song J, Kuruvilla L, et al.
Dev Cell
. 2022 Feb;
57(3):387-397.e4.
PMID: 35134345
Lipid droplets (LDs) are organelles of cellular lipid storage with fundamental roles in energy metabolism and cell membrane homeostasis. There has been an explosion of research into the biology of...
10.
Sienski G, Narayan P, Bonner J, Kory N, Boland S, Arczewska A, et al.
Sci Transl Med
. 2021 Mar;
13(583).
PMID: 33658354
The allele of the apolipoprotein E gene () has been established as a genetic risk factor for many diseases including cardiovascular diseases and Alzheimer's disease (AD), yet its mechanism of...