Laura E Edgington-Mitchell
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Explore the profile of Laura E Edgington-Mitchell including associated specialties, affiliations and a list of published articles.
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39
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382
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Recent Articles
1.
Xu B, Mountford S, Thompson P, Edgington-Mitchell L
ACS Omega
. 2024 Nov;
9(43):43940-43947.
PMID: 39494001
Covalent activity-based probes are invaluable tools to monitor protease activity in vitro and in vivo. We recently discovered that dimethyl sulfoxonium ylides (SYs) bind selectively to cysteine cathepsin proteases in...
2.
Ziegler A, Anderson B, Latorre R, McQuade R, Dufour A, Schmidt B, et al.
J Cell Physiol
. 2024 Oct;
240(1):e31466.
PMID: 39392222
Legumain is a cysteine protease broadly associated with inflammation. It has been reported to cleave and activate protease-activated receptor 2 to provoke pain associated with oral cancer. Outside of gastric...
3.
Xu B, Anderson B, Mintern J, Edgington-Mitchell L
Immunol Cell Biol
. 2024 Jul;
102(9):787-800.
PMID: 38979698
Cysteine cathepsins are lysosomal proteases subject to dynamic regulation within antigen-presenting cells during the immune response and associated diseases. To investigate the regulation of cathepsin X, a carboxy-mono-exopeptidase, during maturation...
4.
Xu B, Anderson B, Mountford S, Thompson P, Mintern J, Edgington-Mitchell L
Biol Chem
. 2024 Feb;
405(5):351-365.
PMID: 38410910
Proteases function within sophisticated networks. Altering the activity of one protease can have sweeping effects on other proteases, leading to changes in their activity, structure, specificity, localisation, stability, and expression....
5.
Ziegler A, Dufour A, Scott N, Edgington-Mitchell L
Mol Cell Proteomics
. 2024 Jan;
23(2):100714.
PMID: 38199506
Aberrant levels of the asparaginyl endopeptidase legumain have been linked to inflammation, neurodegeneration, and cancer, yet our understanding of this protease is incomplete. Systematic attempts to identify legumain substrates have...
6.
Lee I, Tantisirivat P, Edgington-Mitchell L
ACS Bio Med Chem Au
. 2023 Aug;
3(4):295-304.
PMID: 37599791
Protease-activated receptors (PARs) comprise a family of four G protein-coupled receptors (GPCRs) that have broad functions in health and disease. Unlike most GPCRs, PARs are uniquely activated by proteolytic cleavage...
7.
Bird L, Edgington-Mitchell L, Newton H
Curr Opin Immunol
. 2023 May;
83:102344.
PMID: 37245414
The mammalian lysosome is classically considered the 'garbage can' of the cell, contributing to clearance of infection through its primary function as a degradative organelle. Intracellular pathogens have evolved several...
8.
Peach C, Edgington-Mitchell L, Bunnett N, Schmidt B
Physiol Rev
. 2022 Jul;
103(1):717-785.
PMID: 35901239
Proteases are signaling molecules that specifically control cellular functions by cleaving protease-activated receptors (PARs). The four known PARs are members of the large family of G protein-coupled receptors. These transmembrane...
9.
Liu H, Wilson K, Firth A, Macri C, Schriek P, Blum A, et al.
Nat Commun
. 2022 Apr;
13(1):1934.
PMID: 35411049
The MARCH E3 ubiquitin (Ub) ligase MARCH1 regulates trafficking of major histocompatibility complex class II (MHC II) and CD86, molecules of critical importance to immunity. Here we show, using a...
10.
Kim M, Hardy M, Edgington-Mitchell L, Ramarathinam S, Chung S, Russell A, et al.
iScience
. 2021 Dec;
24(12):103509.
PMID: 34934928
Although hydroxychloroquine (HCQ) has long been used to treat autoimmune diseases, its mechanism of action remains poorly understood. In CD4 T-cells, we found that a clinically relevant concentration of HCQ...