Laura Baranello
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Explore the profile of Laura Baranello including associated specialties, affiliations and a list of published articles.
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36
Citations
1533
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Recent Articles
1.
Lee T, Qiao C, Kuzin V, Shi Y, Ramanaranayan V, Wu T, et al.
bioRxiv
. 2024 Nov;
PMID: 39484415
DNA transactions introduce torsional constraints that pose an inherent risk to genome integrity. While topoisomerase 1 (TOP1) activity is essential for removing DNA supercoiling, aberrant stabilization of TOP1:DNA cleavage complexes...
2.
Cameron D, Grosser J, Ladigan S, Kuzin V, Iliopoulou E, Wiegard A, et al.
Sci Adv
. 2023 Oct;
9(41):eadg5109.
PMID: 37831776
Pancreatic carcinoma lacks effective therapeutic strategies resulting in poor prognosis. Transcriptional dysregulation due to alterations in KRAS and MYC affects initiation, development, and survival of this tumor type. Using patient-derived...
3.
Pederiva C, Trevisan D, Peirasmaki D, Chen S, Savage S, Larsson O, et al.
Sci Adv
. 2023 Jul;
9(30):eadg1805.
PMID: 37506213
Posttranscriptional modifications of mRNA have emerged as regulators of gene expression. Although pseudouridylation is the most abundant, its biological role remains poorly understood. Here, we demonstrate that the pseudouridine synthase...
4.
Castell A, Yan Q, Fawkner K, Bazzar W, Zhang F, Wickstrom M, et al.
Cancer Res Commun
. 2023 Mar;
2(3):182-201.
PMID: 36874405
Significance: Our findings demonstrate that the small-molecule MYCMI-7 binds MYC and inhibits interaction between MYC and MAX, thereby hampering MYC-driven tumor cell growth in culture and while sparing normal cells.
5.
Meroni A, Grosser J, Agashe S, Ramakrishnan N, Jackson J, Verma P, et al.
Sci Adv
. 2022 Dec;
8(49):eabq0648.
PMID: 36490343
DNA topoisomerase 1 (TOP11) inhibitors are mainstays of anticancer therapy. These drugs trap TOP1 on DNA, stabilizing the TOP1-cleavage complex (TOP1-cc). The accumulation of TOP1-ccs perturbs DNA replication fork progression,...
6.
Kuzin V, Wiegard A, Cameron D, Baranello L
STAR Protoc
. 2022 Aug;
3(3):101581.
PMID: 35942340
TOP1 CAD-seq enables mapping of TOP1 sites of covalent engagement with DNA. The procedure depends upon enrichment of DNA-covalent adducts using chaotropic salts and immunoprecipitation with an antibody specific for...
7.
Das S, Kuzin V, Cameron D, Sanford S, Jha R, Nie Z, et al.
Mol Cell
. 2021 Dec;
82(1):140-158.e12.
PMID: 34890565
High-intensity transcription and replication supercoil DNA to levels that can impede or halt these processes. As a potent transcription amplifier and replication accelerator, the proto-oncogene MYC must manage this interfering...
8.
Wiegard A, Kuzin V, Cameron D, Grosser J, Ceribelli M, Mehmood R, et al.
Mol Cell
. 2021 Nov;
81(24):5007-5024.e9.
PMID: 34767771
As cells enter mitosis, chromatin compacts to facilitate chromosome segregation yet remains transcribed. Transcription supercoils DNA to levels that can impede further progression of RNA polymerase II (RNAPII) unless it...
9.
Li J, Nagy N, Liu J, Gupta S, Frisan T, Hennig T, et al.
PLoS Pathog
. 2021 Sep;
17(9):e1009954.
PMID: 34543352
Topoisomerases are essential for the replication of herpesviruses but the mechanisms by which the viruses hijack the cellular enzymes are largely unknown. We found that topoisomerase-II (TOP2) is a substrate...
10.
Wu P, Grosser J, Cameron D, Baranello L, Strom L
PLoS Genet
. 2021 Sep;
17(9):e1009763.
PMID: 34499654
The structural maintenance of chromosome (SMC) complex cohesin mediates sister chromatid cohesion established during replication, and damage-induced cohesion formed in response to DSBs post-replication. The translesion synthesis polymerase Polη is...