Fedor Kouzine
Overview
Explore the profile of Fedor Kouzine including associated specialties, affiliations and a list of published articles.
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Articles
30
Citations
1423
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0
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Recent Articles
1.
Jha R, Kouzine F, Levens D
Front Cell Dev Biol
. 2023 Nov;
11:1268275.
PMID: 37941901
MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier that regulates almost every physiological process in a cell including cell cycle, proliferation, metabolism, differentiation, and apoptosis....
2.
Kouzine F, Wojtowicz D, Przytycka T, Levens D
Methods Mol Biol
. 2023 Mar;
2651:179-193.
PMID: 36892768
Z-DNAs are nucleic acid secondary structures that form within a special pattern of nucleotides and are promoted by DNA supercoiling. Through Z-DNA formation, DNA encodes information by dynamic changes in...
3.
Jha R, Levens D, Kouzine F
Nucleus
. 2022 Feb;
13(1):94-115.
PMID: 35220881
The compaction of linear DNA into micrometer-sized nuclear boundaries involves the establishment of specific three-dimensional (3D) DNA structures complexed with histone proteins that form chromatin. The resulting structures modulate essential...
4.
Shaheen C, Hastie C, Metera K, Scott S, Zhang Z, Chen S, et al.
Nucleic Acids Res
. 2022 Feb;
50(5):2754-2764.
PMID: 35188541
Many cellular processes occur out of equilibrium. This includes site-specific unwinding in supercoiled DNA, which may play an important role in gene regulation. Here, we use the Convex Lens-induced Confinement...
5.
Das S, Kuzin V, Cameron D, Sanford S, Jha R, Nie Z, et al.
Mol Cell
. 2021 Dec;
82(1):140-158.e12.
PMID: 34890565
High-intensity transcription and replication supercoil DNA to levels that can impede or halt these processes. As a potent transcription amplifier and replication accelerator, the proto-oncogene MYC must manage this interfering...
6.
Wiegard A, Kuzin V, Cameron D, Grosser J, Ceribelli M, Mehmood R, et al.
Mol Cell
. 2021 Nov;
81(24):5007-5024.e9.
PMID: 34767771
As cells enter mitosis, chromatin compacts to facilitate chromosome segregation yet remains transcribed. Transcription supercoils DNA to levels that can impede further progression of RNA polymerase II (RNAPII) unless it...
7.
Kouzine F, Levens D
Cell
. 2019 Oct;
179(3):579-581.
PMID: 31626764
DNA-replication machinery introduces intertwining and supercoiling of DNA strands as it traverses the double helix, which could impede replication and compromise genome stability. A new study in Cell shows that...
8.
Kouzine F, Wojtowicz D, Yamane A, Casellas R, Przytycka T, Levens D
Methods Mol Biol
. 2019 Aug;
2035:369-382.
PMID: 31444763
While DNA inside the cells is predominantly canonical right-handed double helix, guanine-rich DNAs have potential to fold into four-stranded structures that contain stacks of G-quartets (G4 DNA quadruplex). Genome sequencing...
9.
Scott S, Shaheen C, McGuinness B, Metera K, Kouzine F, Levens D, et al.
Nucleic Acids Res
. 2019 May;
47(12):6360-6368.
PMID: 31106378
DNA unwinding is an important cellular process involved in DNA replication, transcription and repair. In cells, molecular crowding caused by the presence of organelles, proteins, and other molecules affects numerous...
10.
Scott S, Xu Z, Kouzine F, Berard D, Shaheen C, Gravel B, et al.
Nucleic Acids Res
. 2018 Apr;
46(9):4622-4631.
PMID: 29684182
We directly visualize the topology-mediated interactions between an unwinding site on a supercoiled DNA plasmid and a specific probe molecule designed to bind to this site, as a function of...