Rafael Casellas
Overview
Explore the profile of Rafael Casellas including associated specialties, affiliations and a list of published articles.
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86
Citations
8945
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Recent Articles
1.
Sebastian R, Sun E, Fedkenheuer M, Fu H, Jung S, Thakur B, et al.
Nature
. 2025 Feb;
PMID: 39972127
DNA double-strand breaks (DSBs) disrupt the continuity of the genome, with consequences for malignant transformation. Massive DNA damage can elicit a cellular checkpoint response that prevents cell proliferation. However, how...
2.
Fedkenheuer M, Shang Y, Jung S, Fedkenheuer K, Park S, Mazza D, et al.
Nat Commun
. 2025 Jan;
16(1):843.
PMID: 39833168
Cells undergo tens of thousands of DNA-damaging events each day. Defects in repairing double-stranded breaks (DSBs) can lead to genomic instability, contributing to cancer, genetic disorders, immunological diseases, and developmental...
3.
Trzaskoma P, Jung S, Pekowska A, Bohrer C, Wang X, Naz F, et al.
Sci Adv
. 2024 Aug;
10(32):eadl4893.
PMID: 39121214
Discontinuous transcription is evolutionarily conserved and a fundamental feature of gene regulation; yet, the exact mechanisms underlying transcriptional bursting are unresolved. Analyses of bursting transcriptome-wide have focused on the role...
4.
Zhao H, Li J, Xiang Y, Malik S, Vartak S, Veronezi G, et al.
Mol Cell
. 2024 Jul;
84(14):2648-2664.e10.
PMID: 38955181
The essential Mediator (MED) coactivator complex plays a well-understood role in regulation of basal transcription in all eukaryotes, but the mechanism underlying its role in activator-dependent transcription remains unknown. We...
5.
Xu J, Zhou T, McKee K, Zhang B, Liu C, Nazzari A, et al.
Adv Sci (Weinh)
. 2024 May;
11(26):e2309268.
PMID: 38704686
Broadly neutralizing antibodies are proposed as therapeutic and prophylactic agents against HIV-1, but their potency and breadth are less than optimal. This study describes the immunization of a llama with...
6.
Kim M, Wang P, Clow P, Chien I, Wang X, Peng J, et al.
bioRxiv
. 2024 Apr;
PMID: 38585764
Cohesin is required for chromatin loop formation. However, its precise role in regulating gene transcription remains largely unknown. We investigated the relationship between cohesin and RNA Polymerase II (RNAPII) using...
7.
Zhu K, Celwyn I, Guan D, Xiao Y, Wang X, Hu W, et al.
Mol Cell
. 2023 Oct;
83(19):3457-3469.e7.
PMID: 37802023
Circadian gene transcription is fundamental to metabolic physiology. Here we report that the nuclear receptor REV-ERBα, a repressive component of the molecular clock, forms circadian condensates in the nuclei of...
8.
Zhao Y, Vartak S, Conte A, Wang X, Garcia D, Stevens E, et al.
Mol Cell
. 2022 Jul;
82(18):3398-3411.e11.
PMID: 35863348
Regulatory elements activate promoters by recruiting transcription factors (TFs) to specific motifs. Notably, TF-DNA interactions often depend on cooperativity with colocalized partners, suggesting an underlying cis-regulatory syntax. To explore TF...
9.
Xie L, Dong P, Qi Y, Hsieh T, English B, Jung S, et al.
Nat Genet
. 2022 Apr;
54(4):481-491.
PMID: 35410381
Mammalian chromosomes are organized into megabase-sized compartments that are further subdivided into topologically associating domains (TADs). While the formation of TADs is dependent on cohesin, the mechanism behind compartmentalization remains...
10.
Xu J, Xu K, Jung S, Conte A, Lieberman J, Muecksch F, et al.
Nature
. 2021 Jun;
595(7866):278-282.
PMID: 34098567
Since the start of the COVID-19 pandemic, SARS-CoV-2 has caused millions of deaths worldwide. Although a number of vaccines have been deployed, the continual evolution of the receptor-binding domain (RBD)...