Laura Amori
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Explore the profile of Laura Amori including associated specialties, affiliations and a list of published articles.
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14
Citations
285
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Recent Articles
1.
Bruno A, Amori L, Costantino G
Mol Inform
. 2016 Aug;
32(5-6):447-57.
PMID: 27481665
O-Acetylserine sulfhydrylase (isoform A, OASS-A) is a PLP-dependent enzyme involved in the last step of cysteine biosynthesis in many pathogens. Many microorganisms use cysteine as the main building block for...
2.
Bruno A, Amori L, Costantino G
Mol Inform
. 2016 Jul;
30(4):317-28.
PMID: 27466949
Serine racemase (SR) is a PLP-dependent enzyme catalyzing the racemization of L-Ser into D-Ser, which is now recognized as an endogenous co-agonist at the NMDA receptor complex. As indicated by...
3.
Vallerini G, Amori L, Beato C, Tararina M, Wang X, Schwarcz R, et al.
J Med Chem
. 2013 Nov;
56(23):9482-95.
PMID: 24274468
3-Hydroxyanthranilic acid 3,4-dioxygenase (3-HAO) is the enzyme responsible for the production of the neurotoxic tryptophan metabolite quinolinic acid (QUIN). Elevated brain levels of QUIN are observed in several neurodegenerative diseases,...
4.
Rivara M, Patel M, Amori L, Zuliani V
Bioorg Med Chem Lett
. 2012 Sep;
22(20):6401-4.
PMID: 22981330
We have synthesized and evaluated a series of 1,4-disubstituted-triazole derivatives for inhibition of the rat Na(V)1.6 sodium channel isoform, an isoform thought to play an important role in controlling neuronal...
5.
Perez-De la Cruz V, Amori L, Sathyasaikumar K, Wang X, Notarangelo F, Wu H, et al.
J Neurochem
. 2012 Jan;
120(6):1026-35.
PMID: 22224417
In the mammalian brain, the α7 nicotinic and NMDA receptor antagonist kynurenic acid is synthesized by irreversible enzymatic transamination of the tryptophan metabolite l-kynurenine. d-kynurenine, too, serves as a bioprecursor...
6.
Sathyasaikumar K, Stachowski E, Amori L, Guidetti P, Muchowski P, Schwarcz R
J Neurochem
. 2010 Mar;
113(6):1416-25.
PMID: 20236387
Elevated concentrations of neurotoxic metabolites of the kynurenine pathway (KP) of tryptophan degradation may play a causative role in Huntington's disease (HD). The brain levels of one of these compounds,...
7.
Amori L, Guidetti P, Pellicciari R, Kajii Y, Schwarcz R
J Neurochem
. 2009 Feb;
109(2):316-25.
PMID: 19226371
In the mammalian brain, kynurenine aminotransferase II (KAT II) and kynurenine 3-monooxygenase (KMO), key enzymes of the kynurenine pathway (KP) of tryptophan degradation, form the neuroactive metabolites kynurenic acid (KYNA)...
8.
Pellicciari R, Venturoni F, Bellocchi D, Carotti A, Marinozzi M, Macchiarulo A, et al.
ChemMedChem
. 2008 Jun;
3(8):1199-202.
PMID: 18537204
No abstract available.
9.
Mitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brain
Guidetti P, Amori L, Sapko M, Okuno E, Schwarcz R
J Neurochem
. 2007 Apr;
102(1):103-11.
PMID: 17442055
The tryptophan metabolite kynurenic acid (KYNA), which is produced enzymatically by the irreversible transamination of l-kynurenine, is an antagonist of alpha7 nicotinic and NMDA receptors and may thus modulate cholinergic...
10.
Marinozzi M, Serpi M, Amori L, Gavilan Diaz M, Costantino G, Meyer U, et al.
Bioorg Med Chem
. 2007 Mar;
15(9):3161-70.
PMID: 17350267
Four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine were synthesized by a stereocontrolled synthetic procedure and evaluated as mGluRs ligands. The (2S,1'R,2'S,3'R)-isomer (PPCG-2) showed to be a group III mGluRs selective ligand endowed with...