Lars Maegdefessel
Overview
Explore the profile of Lars Maegdefessel including associated specialties, affiliations and a list of published articles.
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176
Citations
4960
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Recent Articles
21.
Sharifi M, Wierer M, Dang T, Milic J, Moggio A, Sachs N, et al.
Circ Res
. 2023 Sep;
133(8):674-686.
PMID: 37675562
Background: The locus was genome-wide significantly associated with coronary artery disease. Lack of the ECM (extracellular matrix) protease ADAMTS-7 (A disintegrin and metalloproteinase-7) was shown to reduce atherosclerotic plaque formation....
22.
Martinez M, Ritsvall O, Bastrup J, Celik S, Jakobsson G, Daoud F, et al.
JCI Insight
. 2023 Aug;
8(17).
PMID: 37561588
Inadequate adaption to mechanical forces, including blood pressure, contributes to development of arterial aneurysms. Recent studies have pointed to a mechanoprotective role of YAP and TAZ in vascular smooth muscle...
23.
von Scheidt M, Bauer S, Ma A, Hao K, Kessler T, Vilne B, et al.
medRxiv
. 2023 Aug;
PMID: 37546840
Background: Leukocyte progenitors derived from clonal hematopoiesis of undetermined potential (CHIP) are associated with increased cardiovascular events. However, the prevalence and functional relevance of CHIP in coronary artery disease (CAD)...
24.
Pauli J, Reisenauer T, Winski G, Sachs N, Chernogubova E, Freytag H, et al.
Biomolecules
. 2023 Jul;
13(7).
PMID: 37509110
Popliteal artery aneurysm (PAA) is the most frequent peripheral aneurysm, primarily seen in male smokers with a prevalence below 1%. This exploratory study aims to shed light on cellular mechanisms...
25.
Bashore A, Yan H, Xue C, Zhu L, Kim E, Mawson T, et al.
medRxiv
. 2023 Jul;
PMID: 37502836
Background: Atherosclerotic plaques are complex tissues composed of a heterogeneous mixture of cells. However, we have limited understanding of the comprehensive transcriptional and phenotypical landscape of the cells within these...
26.
Zhang W, Zhao J, Deng L, Ishimwe N, Pauli J, Wu W, et al.
Circulation
. 2023 May;
148(1):47-67.
PMID: 37199168
Background: Activation of vascular smooth muscle cell (VSMC) inflammation is vital to initiate vascular disease. The role of human-specific long noncoding RNAs in VSMC inflammation is poorly understood. Methods: Bulk...
27.
Winter H, Maegdefessel L
Eur Heart J
. 2023 May;
44(25):2267-2269.
PMID: 37165511
No abstract available.
28.
Winter H, Winski G, Busch A, Chernogubova E, Fasolo F, Wu Z, et al.
Mol Ther
. 2023 May;
31(6):1775-1790.
PMID: 37147804
Long non-coding RNAs (lncRNAs) orchestrate various biological processes and regulate the development of cardiovascular diseases. Their potential therapeutic benefit to tackle disease progression has recently been extensively explored. Our study...
29.
Bink D, Pauli J, Maegdefessel L, Boon R
Atherosclerosis
. 2023 Apr;
374:99-106.
PMID: 37059656
Atherosclerosis and numerous other cardiovascular diseases develop in an age-dependent manner. The endothelial cells that line the vessel walls play an important role in the development of atherosclerosis. Non-coding RNA...
30.
Skenteris N, Hemme E, Delfos L, Karadimou G, Karlof E, Lengquist M, et al.
Vascul Pharmacol
. 2023 Mar;
150:107167.
PMID: 36958707
Background: Calcification, a key feature of advanced human atherosclerosis, is positively associated with vascular disease burden and adverse events. We showed that macrocalcification can be a stabilizing factor for carotid...