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Lars Maegdefessel

Explore the profile of Lars Maegdefessel including associated specialties, affiliations and a list of published articles. Areas
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Articles 176
Citations 4960
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Recent Articles
11.
Pourteymour S, Fan J, Majhi R, Guo S, Sun X, Huang Z, et al.
Cell Mol Life Sci . 2024 Aug; 81(1):331. PMID: 39107572
The rising incidences of atherosclerosis have necessitated efforts to identify novel targets for therapeutic interventions. In the present study, we observed increased expression of the mechanosensitive calcium channel Piezo1 transcript...
12.
Wang Y, Li G, Chen B, Shakir G, Volz M, van der Vorst E, et al.
Cardiovasc Res . 2024 Jun; 120(12):1411-1426. PMID: 38838211
Aims: Although the cannabinoid CB1 receptor has been implicated in atherosclerosis, its cell-specific effects in this disease are not well understood. To address this, we generated a transgenic mouse model...
13.
Pan H, Ho S, Xue C, Cui J, Johanson Q, Sachs N, et al.
Circulation . 2024 Apr; 149(24):1885-1898. PMID: 38686559
Background: Atherosclerosis, a leading cause of cardiovascular disease, involves the pathological activation of various cell types, including immunocytes (eg, macrophages and T cells), smooth muscle cells (SMCs), and endothelial cells....
14.
Ducommun S, Jannig P, Cervenka I, Murgia M, Mittenbuhler M, Chernogubova E, et al.
Mol Metab . 2024 Mar; 82:101912. PMID: 38458566
Objective: Skeletal muscle plasticity and remodeling are critical for adapting tissue function to use, disuse, and regeneration. The aim of this study was to identify genes and molecular pathways that...
15.
Bashore A, Yan H, Xue C, Zhu L, Kim E, Mawson T, et al.
Arterioscler Thromb Vasc Biol . 2024 Feb; 44(4):930-945. PMID: 38385291
Background: Atherosclerotic plaques are complex tissues composed of a heterogeneous mixture of cells. However, our understanding of the comprehensive transcriptional and phenotypic landscape of the cells within these lesions is...
16.
Fidler T, Dunbar A, Kim E, Hardaway B, Pauli J, Xue C, et al.
Nat Cardiovasc Res . 2024 Feb; 3(1):60-75. PMID: 38362011
Clonal hematopoiesis (CH) is an independent risk factor for atherosclerotic cardiovascular disease. Murine models of CH suggest a central role of inflammasomes and IL-1β in accelerated atherosclerosis and plaque destabilization....
17.
Maegdefessel L, Boon R, Dimmeler S
Arterioscler Thromb Vasc Biol . 2023 Dec; 44(1):3-6. PMID: 38150514
No abstract available.
18.
Steffens S, Schroder K, Kruger M, Maack C, Streckfuss-Bomeke K, Backs J, et al.
Clin Res Cardiol . 2023 Oct; 113(5):672-679. PMID: 37847314
The sharing and documentation of cardiovascular research data are essential for efficient use and reuse of data, thereby aiding scientific transparency, accelerating the progress of cardiovascular research and healthcare, and...
19.
Paloschi V, Pauli J, Winski G, Wu Z, Li Z, Botti L, et al.
Adv Healthc Mater . 2023 Oct; 13(6):e2302907. PMID: 37797407
In this study, organ-on-chip technology is used to develop an in vitro model of medium-to-large size arteries, the artery-on-a-chip (AoC), with the objective to recapitulate the structure of the arterial...
20.
Fasolo F, Winski G, Li Z, Wu Z, Winter H, Ritzer J, et al.
Mol Ther Nucleic Acids . 2023 Sep; 33:848-865. PMID: 37680984
An abdominal aortic aneurysm (AAA) is a pathological widening of the aortic wall characterized by loss of smooth muscle cells (SMCs), extracellular matrix degradation, and local inflammation. This condition is...