Lars E T Jansen
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Explore the profile of Lars E T Jansen including associated specialties, affiliations and a list of published articles.
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39
Citations
2745
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Recent Articles
31.
Silva M, Jansen L
Chromosoma
. 2009 Jul;
118(5):567-74.
PMID: 19590885
Centromeres, the chromosomal loci that form the sites of attachment for spindle microtubules during mitosis, are identified by a unique chromatin structure generated by nucleosomes containing the histone H3 variant...
32.
Carroll C, Silva M, Godek K, Jansen L, Straight A
Nat Cell Biol
. 2009 Jun;
11(7):896-902.
PMID: 19543270
Centromeres are specialized chromosomal domains that direct kinetochore assembly during mitosis. CENP-A (centromere protein A), a histone H3-variant present exclusively in centromeric nucleosomes, is thought to function as an epigenetic...
33.
Foltz D, Jansen L, Bailey A, Yates 3rd J, Bassett E, Wood S, et al.
Cell
. 2009 May;
137(3):472-84.
PMID: 19410544
The centromere is responsible for accurate chromosome segregation. Mammalian centromeres are specified epigenetically, with all active centromeres containing centromere-specific chromatin in which CENP-A replaces histone H3 within the nucleosome. The...
34.
Jansen L, Black B, Foltz D, Cleveland D
J Cell Biol
. 2007 Mar;
176(6):795-805.
PMID: 17339380
Centromeres direct chromosomal inheritance by nucleating assembly of the kinetochore, a large multiprotein complex required for microtubule attachment during mitosis. Centromere identity in humans is epigenetically determined, with no DNA...
35.
Black B, Jansen L, Maddox P, Foltz D, Desai A, Shah J, et al.
Mol Cell
. 2007 Jan;
25(2):309-22.
PMID: 17244537
Active centromeres are marked by nucleosomes assembled with CENP-A, a centromere-specific histone H3 variant. The CENP-A centromere targeting domain (CATD), comprised of loop 1 and the alpha2 helix within the...
36.
Foltz D, Jansen L, Black B, Bailey A, Yates 3rd J, Cleveland D
Nat Cell Biol
. 2006 Apr;
8(5):458-69.
PMID: 16622419
The basic element for chromosome inheritance, the centromere, is epigenetically determined in mammals. The prime candidate for specifying centromere identity is the array of nucleosomes assembled with CENP-A, the centromere-specific...
37.
Kobayashi M, Figaroa F, Meeuwenoord N, Jansen L, Siegal G
J Biol Chem
. 2005 Dec;
281(7):4308-17.
PMID: 16361700
BRCT domains, present in a large number of proteins that are involved in cell cycle regulation and/or DNA replication or repair, are primarily thought to be involved in protein-protein interactions....
38.
van Waardenburg R, de Jong L, van Eijndhoven M, Verseyden C, Pluim D, Jansen L, et al.
J Biol Chem
. 2004 Oct;
279(52):54502-9.
PMID: 15471886
Camptothecins constitute a novel class of chemotherapeutics that selectively target DNA topoisomerase I (Top1) by reversibly stabilizing a covalent enzyme-DNA intermediate. This cytotoxic mechanism contrasts with that of platinum drugs,...
39.
Jansen L, Belo A, Hulsker R, Brouwer J
Nucleic Acids Res
. 2002 Aug;
30(16):3532-9.
PMID: 12177294
Previously, we found that Rad26, the yeast Cockayne syndrome B homolog and the transcription elongation factor Spt4 mediate transcription-coupled repair of UV-induced DNA damage. Here we studied the effect of...