Lars E T Jansen
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Explore the profile of Lars E T Jansen including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
2745
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Recent Articles
1.
Tehrani S, Kogan A, Mikulski P, Jansen L
Cell Death Differ
. 2023 Aug;
32(1):16-26.
PMID: 37563261
Transcriptional memory is characterized by a primed cellular state, induced by an external stimulus that results in an altered expression of primed genes upon re-exposure to the inducing signal. Intriguingly,...
2.
van den Berg S, Jansen L
Front Cell Dev Biol
. 2023 May;
11:1193192.
PMID: 37181753
Centromeres are unique chromosomal loci that form the anchorage point for the mitotic spindle during mitosis and meiosis. Their position and function are specified by a unique chromatin domain featuring...
3.
van den Berg S, East S, Mitra S, Jansen L
Mol Biol Cell
. 2023 Mar;
34(5):br6.
PMID: 36989032
The centromere is a unique chromatin domain that links sister chromatids and forms the attachment site for spindle microtubules in mitosis. Centromere inheritance is largely DNA sequence-independent but strongly reliant...
4.
Gabriel L, Srinivasan B, Kus K, Mata J, Amorim M, Jansen L, et al.
J Cell Sci
. 2021 May;
134(10).
PMID: 34037233
Zα domains recognize the left-handed helical Z conformation of double-stranded nucleic acids. They are found in proteins involved in the nucleic acid sensory pathway of the vertebrate innate immune system...
5.
Stajic D, Jansen L
Philos Trans R Soc Lond B Biol Sci
. 2021 Apr;
376(1826):20200121.
PMID: 33866813
The cellular machinery that regulates gene expression can be self-propagated across cell division cycles and even generations. This renders gene expression states and their associated phenotypes heritable, independently of genetic...
6.
Murillo-Pineda M, Valente L, Dumont M, Mata J, Fachinetti D, Jansen L
J Cell Biol
. 2021 Jan;
220(3).
PMID: 33443568
Human centromeres form primarily on α-satellite DNA but sporadically arise de novo at naive ectopic loci, creating neocentromeres. Centromere inheritance is driven primarily by chromatin containing the histone H3 variant...
7.
Siwek W, Tehrani S, Mata J, Jansen L
Mol Cell
. 2020 Oct;
80(3):396-409.e6.
PMID: 33108759
Cytokine activation of cells induces gene networks involved in inflammation and immunity. Transient gene activation can have a lasting effect even in the absence of ongoing transcription, known as long-term...
8.
Milagre I, Pereira C, Oliveira R, Jansen L
Open Biol
. 2020 Oct;
10(10):200227.
PMID: 33081635
Pluripotent stem cells (PSCs) are central to development as they are the precursors of all cell types in the embryo. Therefore, maintaining a stable karyotype is essential, both for their...
9.
Mitra S, Srinivasan B, Jansen L
J Cell Biol
. 2020 Sep;
219(10).
PMID: 32931551
Chromosome segregation during cell division is driven by mitotic spindle attachment to the centromere region on each chromosome. Centromeres form a protein scaffold defined by chromatin featuring CENP-A, a conserved...
10.
Bobkov G, Huang A, van den Berg S, Mitra S, Anselm E, Lazou V, et al.
Nat Commun
. 2020 Jun;
11(1):2919.
PMID: 32522980
Replication and transcription of genomic DNA requires partial disassembly of nucleosomes to allow progression of polymerases. This presents both an opportunity to remodel the underlying chromatin and a danger of...