Larry N Singh
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Explore the profile of Larry N Singh including associated specialties, affiliations and a list of published articles.
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43
Citations
1859
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Recent Articles
1.
Simmons N, Ingala M, Pieri M, L Volkert T, Singh L, Philip P, et al.
Wellcome Open Res
. 2023 Aug;
8:198.
PMID: 37600588
We present a genome assembly from an individual male (Chordata; Mammalia; Chiroptera; Molossidae). The genome sequence is 2.41 gigabases in span. The majority of the assembly is scaffolded into 24...
2.
Guarnieri J, Dybas J, Fazelinia H, Kim M, Frere J, Zhang Y, et al.
Sci Transl Med
. 2023 Aug;
15(708):eabq1533.
PMID: 37556555
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins bind to host mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating glycolysis. We analyzed mitochondrial gene expression in nasopharyngeal and...
3.
Carrell E, Chen Y, Ranum P, Coffin S, Singh L, Tecedor L, et al.
Mol Ther Nucleic Acids
. 2023 Aug;
33:296-304.
PMID: 37547292
Recombinant adeno-associated viral vectors (rAAVs) are a promising strategy to treat neurodegenerative diseases because of their ability to infect non-dividing cells and confer long-term transgene expression. Despite an ever-growing library...
4.
Senthil K, Hefti M, Singh L, Morgan R, Mavroudis C, Ko T, et al.
Resusc Plus
. 2022 May;
10:100243.
PMID: 35592874
Objective: The effect of cardiac arrest (CA) on cerebral transcriptomics and metabolomics is unknown. We previously demonstrated hemodynamic-directed CPR (HD-CPR) improves survival with favorable neurologic outcomes versus standard CPR (Std-CPR)....
5.
Guarnieri J, Dybas J, Fazelinia H, Kim M, Frere J, Zhang Y, et al.
bioRxiv
. 2022 Mar;
PMID: 35233572
Defects in mitochondrial oxidative phosphorylation (OXPHOS) have been reported in COVID-19 patients, but the timing and organs affected vary among reports. Here, we reveal the dynamics of COVID-19 through transcription...
6.
Singh L, Kao S, Wallace D
Cells
. 2021 Dec;
10(12).
PMID: 34943968
Neurodegenerative disorders that are triggered by injury typically have variable and unpredictable outcomes due to the complex and multifactorial cascade of events following the injury and during recovery. Hence, several...
7.
Singh L, Ennis B, Loneragan B, Tsao N, Lopez Sanchez M, Li J, et al.
PLoS Comput Biol
. 2021 Nov;
17(11):e1009594.
PMID: 34762648
The growing number of next-generation sequencing (NGS) data presents a unique opportunity to study the combined impact of mitochondrial and nuclear-encoded genetic variation in complex disease. Mitochondrial DNA variants and...
8.
McDonald J, Enguita F, Taylor D, Griffin R, Priebe W, Emmett M, et al.
Cell Rep
. 2021 Oct;
37(3):109839.
PMID: 34624208
MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation that have a major impact on many diseases and provide an exciting avenue toward antiviral therapeutics. From patient transcriptomic...
9.
Towheed A, Hietanen C, Kamath V, Singh L, Ho A, Engelstad K, et al.
Ann Clin Transl Neurol
. 2021 Oct;
8(11):2199-2204.
PMID: 34612606
Two siblings presented similarly with congenital hypotonia, lactic acidosis, and failure to thrive. Later in childhood, the brother developed cystinuria and nephrolithiasis whereas the older sister suffered from cystinuria and...
10.
Niederschweiberer M, Schaefer P, Singh L, Lausser L, Bhosale D, Hesse R, et al.
Front Mol Biosci
. 2021 Jul;
8:671274.
PMID: 34195227
Alzheimer's disease (AD), the most prevalent form of dementia, affects globally more than 30 million people suffering from cognitive deficits and neuropsychiatric symptoms. Substantial evidence for the involvement of mitochondrial...