Larry K Keefer
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Explore the profile of Larry K Keefer including associated specialties, affiliations and a list of published articles.
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117
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2311
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Recent Articles
1.
Saavedra J, Booth M, Hrabie J, Davies K, Keefer L
J Org Chem
. 2021 Jul;
64(14):5124-5131.
PMID: 34237868
Synthetic procedures have been devised to exploit the bifunctional amine piperazine (pip) as a linker capable of attaching the nitric oxide (NO)-releasing diazeniumdiolate functional group [N(O)NO] to a diverse selection...
2.
Cortese-Krott M, Kuhnle G, Dyson A, Fernandez B, Grman M, DuMond J, et al.
Proc Natl Acad Sci U S A
. 2015 Jul;
112(34):E4651-60.
PMID: 26224837
Experimental evidence suggests that nitric oxide (NO) and hydrogen sulfide (H2S) signaling pathways are intimately intertwined, with mutual attenuation or potentiation of biological responses in the cardiovascular system and elsewhere....
3.
Kim Y, Maciag A, Cao Z, Deschamps J, Saavedra J, Keefer L, et al.
Bioorg Med Chem
. 2015 Jun;
23(15):4980-4988.
PMID: 26043946
PABA/NO [O(2)-{2,4-dinitro-5-[4-(N-methylamino)benzoyloxy]phenyl} 1-(N,N-dimethylamino) diazen-1-ium-1,2-diolate] is a nitric oxide (NO)-releasing arylating agent designed to be selectively activated by reaction with glutathione (GSH) on catalysis by glutathione S-transferase P1 (GSTP1), an enzyme...
4.
Kus K, Walczak M, Maslak E, Zakrzewska A, Gonciarz-Dytman A, Zabielski P, et al.
Drug Metab Dispos
. 2015 Apr;
43(7):1028-36.
PMID: 25870102
V-PYRRO/NO [O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate] and V-PROLI/NO (O2-vinyl-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate), two structurally similar diazeniumdiolate derivatives, were designed as liver-selective prodrugs that are metabolized by cytochrome P450 isoenzymes, with subsequent release of nitric oxide (NO). Yet,...
5.
Maslak E, Zabielski P, Kochan K, Kus K, Jasztal A, Sitek B, et al.
Biochem Pharmacol
. 2014 Dec;
93(3):389-400.
PMID: 25534988
Background And Purpose: There is an unmet medical need for novel NAFLD treatments. Here we have examined the effects of liver-selective NO donor (V-PYRRO/NO) as compared with metformin on hepatic...
6.
Fuhrman B, Xu X, Falk R, Dallal C, Veenstra T, Keefer L, et al.
Cancer Epidemiol Biomarkers Prev
. 2014 Dec;
23(12):2649-57.
PMID: 25472673
Background: Interindividual differences in estrogen metabolism may partially account for differences in risks of estrogen-responsive cancers. We conducted a proof-of-performance study to assess the reproducibility of a LC/MS-MS method for...
7.
Holland R, Klose J, Deschamps J, Cao Z, Keefer L, Saavedra J
J Org Chem
. 2014 Sep;
79(19):9389-93.
PMID: 25210948
We report the apparently unprecedented direct reaction of nitric oxide (NO) with amides to generate ions of structure R(C═O)NH-N(O)═NO(-), with examples including R = Me (1a) or 3-pyridyl (1b). The...
8.
Bharadwaj G, Benini P, Basudhar D, Ramos-Colon C, Johnson G, Larriva M, et al.
Nitric Oxide
. 2014 Sep;
42:70-8.
PMID: 25192820
Nitroxyl (HNO) donors have been shown to elicit a variety of pharmacological responses, ranging from tumoricidal effects to treatment of heart failure. Isopropylamine-based diazeniumdiolates have been shown to produce HNO...
9.
Biswas D, Hrabie J, Saavedra J, Cao Z, Keefer L, Ivanic J, et al.
J Org Chem
. 2014 Apr;
79(10):4512-6.
PMID: 24766285
Recent theoretical studies have suggested that the parent diazeniumdiolate ion, H2N-N(O)═NO(-) ("diazeniumdiolated ammonia"), might be stable enough to be isolated and that it could potentially serve as a uniquely advantageous...
10.
Maciag A, Holland R, Kim Y, Kumari V, Luthers C, Sehareen W, et al.
J Med Chem
. 2014 Feb;
57(6):2292-302.
PMID: 24521039
We report the antitumor effects of nitric oxide (NO) releasing derivatives of the PARP-1 inhibitor olaparib (1). Compound 5b was prepared by coupling the carboxyl group of 3b and the...