Larry C Park
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Explore the profile of Larry C Park including associated specialties, affiliations and a list of published articles.
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14
Citations
536
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Recent Articles
1.
Aaronson J, Beaumont V, Blevins R, Andreeva V, Murasheva I, Shneyderman A, et al.
J Huntingtons Dis
. 2021 Aug;
10(3):405-412.
PMID: 34397420
HDinHD (Huntington's Disease in High Definition; HDinHD.org) is an open online portal for the HD research community that presents a synthesized view of HD-related scientific data. Here, we present a...
2.
Heikkinen T, Bragge T, Bhattarai N, Parkkari T, Puolivali J, Kontkanen O, et al.
PLoS One
. 2020 Dec;
15(12):e0243052.
PMID: 33370315
Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by severe disruption of cognitive and motor functions, including changes in posture and gait. A number of HD mouse models have...
3.
Ghavami A, Olsen M, Kwan M, Beltran J, Shea J, Ramboz S, et al.
J Huntingtons Dis
. 2020 Feb;
9(1):13-31.
PMID: 32007959
Background: Huntington's disease (HD) is a progressive neurodegenerative disorder that prominently affects the basal ganglia, leading to affective, cognitive, behavioral, and motor decline. The primary site of neuron loss in...
4.
Huhtala T, Poutiainen P, Rytkonen J, Lehtimaki K, Parkkari T, Kasanen I, et al.
EJNMMI Radiopharm Chem
. 2019 Oct;
4(1):20.
PMID: 31659519
Purpose: Dopamine receptors are involved in pathophysiology of neuropsychiatric diseases, including Huntington's disease (HD). PET imaging of dopamine D2 receptors (D2R) in HD patients has demonstrated 40% decrease in D2R...
5.
Padovan-Neto F, Jurkowski L, Murray C, Stutzmann G, Kwan M, Ghavami A, et al.
Nitric Oxide
. 2018 Dec;
83:40-50.
PMID: 30528913
In Huntington's disease (HD), corticostriatal and striatopallidal projection neurons preferentially degenerate as a result of mutant huntingtin expression. Pathological deficits in nitric oxide (NO) signaling have also been reported in...
6.
Piiponniemi T, Parkkari T, Heikkinen T, Puolivali J, Park L, Cachope R, et al.
Front Behav Neurosci
. 2018 Oct;
12:226.
PMID: 30333735
Cognitive disturbances often predate characteristic motor dysfunction in individuals with Huntington's disease (HD) and place an increasing burden on the HD patients and caregivers with the progression of the disorder....
7.
Bresciani A, Missineo A, Gallo M, Cerretani M, Fezzardi P, Tomei L, et al.
Arch Biochem Biophys
. 2017 Aug;
631:31-41.
PMID: 28801166
Mechanisms that activate innate antioxidant responses, as a way to mitigate oxidative stress at the site of action, hold much therapeutic potential in diseases, such as Parkinson's disease, Alzheimer's disease...
8.
Naseri N, Bonica J, Xu H, Park L, Arjomand J, Chen Z, et al.
PLoS One
. 2016 Sep;
11(9):e0160384.
PMID: 27611087
Metabolic dysfunction is well-documented in Huntington's disease (HD). However, the link between the mutant huntingtin (mHTT) gene and the pathology is unknown. The tricarboxylic acid (TCA) cycle is the main...
9.
Beaumont V, Mrzljak L, Dijkman U, Freije R, Heins M, Rassoulpour A, et al.
Exp Neurol
. 2016 May;
282:99-118.
PMID: 27163548
Dysregulation of the kynurenine (Kyn) pathway has been associated with the progression of Huntington's disease (HD). In particular, elevated levels of the kynurenine metabolites 3-hydroxy kynurenine (3-OH-Kyn) and quinolinic acid...
10.
Curtin P, Farrar A, Oakeshott S, Sutphen J, Berger J, Mazzella M, et al.
Front Behav Neurosci
. 2016 Jan;
9:361.
PMID: 26793080
Huntington's Disease (HD) is a progressive neurodegenerative disorder that causes motor, cognitive, and psychiatric symptoms. In these experiments, we tested if operant training at an early age affected adult cognitive...