HDinHD: A Rich Data Portal for Huntington's Disease Research

Overview

Journal J Huntingtons Dis

Publisher Sage Publications

Date 2021 Aug 16

PMID 34397420

Citations 7

Authors

Jeff Aaronson

Vahri Beaumont

Richard A Blevins

Viktoria Andreeva

Irina Murasheva

Anastasia Shneyderman

Kabenla Armah

Rob Gill

Jian Chen

Jim Rosinski

Larry C Park

Giovanni Coppola

Ignacio Munoz-Sanjuan

Thomas F Vogt

Affiliations

Soon will be listed here.

Abstract

HDinHD (Huntington's Disease in High Definition; HDinHD.org) is an open online portal for the HD research community that presents a synthesized view of HD-related scientific data. Here, we present a broad overview of HDinHD and highlight the newly launched HDinHD Explorer tool that enables researchers to discover and explore a wide range of diverse yet interconnected HD-related data. We demonstrate the utility of HDinHD Explorer through data mining of a single collection of newly released in vivo therapeutic intervention study reports alongside previously published reports.

Citing Articles

Aberrant splicing in Huntington's disease accompanies disrupted TDP-43 activity and altered m6A RNA modification.

Nguyen T, Miramontes R, Chillon-Marinas C, Maimon R, Vazquez-Sanchez S, Lau A Nat Neurosci. 2025; 28(2):280-292.

PMID: 39762660 PMC: 11802453. DOI: 10.1038/s41593-024-01850-w.

Huntingtin is an RNA binding protein and participates in -mediated paraspeckles.

Yadav M, Harding R, Li T, Xu X, Gall-Duncan T, Khan M Sci Adv. 2024; 10(29):eado5264.

PMID: 39028820 PMC: 11259171. DOI: 10.1126/sciadv.ado5264.

Single nuclei RNA-seq reveals a medium spiny neuron glutamate excitotoxicity signature prior to the onset of neuronal death in an ovine Huntington's disease model.

Jiang A, You L, Handley R, Hawkins V, Reid S, Jacobsen J Hum Mol Genet. 2024; 33(17):1524-1539.

PMID: 38776957 PMC: 11336116. DOI: 10.1093/hmg/ddae087.

HD and SCA1: Tales from two 30-year journeys since gene discovery.

Thompson L, Orr H Neuron. 2023; 111(22):3517-3530.

PMID: 37863037 PMC: 10842341. DOI: 10.1016/j.neuron.2023.09.036.

Celis K, Moreno M, Rajabli F, Whitehead P, Hamilton-Nelson K, Dykxhoorn D Alzheimers Dement. 2023; 19(9):3902-3915.

PMID: 37037656 PMC: 10529851. DOI: 10.1002/alz.13075.