Larry A Harshyne
Overview
Explore the profile of Larry A Harshyne including associated specialties, affiliations and a list of published articles.
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25
Citations
533
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0
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Recent Articles
11.
Andrews D, Judy K, Scott C, Garcia S, Harshyne L, Kenyon L, et al.
Clin Cancer Res
. 2021 Jan;
27(7):1912-1922.
PMID: 33500356
Purpose: Despite standard of care (SOC) established by Stupp, glioblastoma remains a uniformly poor prognosis. We evaluated IGV-001, which combines autologous glioblastoma tumor cells and an antisense oligonucleotide against IGF...
12.
Knops A, South A, Rodeck U, Martinez-Outschoorn U, Harshyne L, Johnson J, et al.
Front Oncol
. 2020 Dec;
10:565306.
PMID: 33330034
Introduction: The progression and clinical course of head and neck squamous cell carcinoma (HNSCC) relies on complex interactions between cancer and stromal cells in the tumor microenvironment (TME). Among the...
13.
Flemming J, Hill B, Haque M, Raad J, Bonder C, Harshyne L, et al.
J Extracell Vesicles
. 2020 Sep;
9(1):1790159.
PMID: 32944178
Abbreviations: Basal cell carcinomas, BCC; Betacellulin, BTC; 2-bromopalmitate, 2-Bromo; Cluster of differentiation, CD; Cytochrome c oxidase IV, COX IV; Desmoglein 2, Dsg2; Early endosome antigen 1, EEA1; Epidermal growth factor...
14.
Fortuna D, Hooper D, Roberts A, Harshyne L, Nagurney M, Curtis M
PLoS One
. 2018 Nov;
13(10):e0205501.
PMID: 30379898
Current laboratory testing of cerebrospinal fluid (CSF) does not consistently discriminate between different central nervous system (CNS) disease states. Rapidly distinguishing CNS infections from other brain and spinal cord disorders...
15.
Lu H, Bowler N, Harshyne L, Hooper D, Krishn S, Kurtoglu S, et al.
Matrix Biol
. 2018 Mar;
70:20-35.
PMID: 29530483
Therapeutic approaches aimed at curing prostate cancer are only partially successful given the occurrence of highly metastatic resistant phenotypes that frequently develop in response to therapies. Recently, we have described...
16.
Topf M, Tuluc M, Harshyne L, Luginbuhl A
J Immunother Cancer
. 2017 Jul;
5(1):60.
PMID: 28716144
Background: The tumor microenvironment often polarizes infiltrating macrophages towards a type 2, or M2 phenotype, that is characterized by expression of various cysteine-rich, scavenger receptors, including CD163. The primary function...
17.
Overmiller A, Pierluissi J, Wermuth P, Sauma S, Martinez-Outschoorn U, Tuluc M, et al.
FASEB J
. 2017 Apr;
31(8):3412-3424.
PMID: 28438789
Extracellular vesicles (EVs) are nanoscale membrane-derived vesicles that serve as intercellular messengers carrying lipids, proteins, and genetic material. Substantial evidence has shown that cancer-derived EVs, secreted by tumor cells into...
18.
Fortuna D, Cardenas A, Graf E, Harshyne L, Hooper D, Prosniak M, et al.
J Clin Virol
. 2016 Dec;
86:39-45.
PMID: 27914285
Background: Human parechovirus (HPeV) and enterovirus (EV) cause a range of human diseases including serious CNS infections. Little is known regarding the immune response to HPeV meningitis compared to EV...
19.
Alexander G, Palmer J, Tuluc M, Lin J, Dicker A, Bar-Ad V, et al.
J Hematol Oncol
. 2016 Sep;
9(1):96.
PMID: 27663515
Background: Pembrolizumab is a monoclonal antibody that is designed against programmed cell death protein 1 (PD-1). Pembrolizumab and other immunocheckpoint-blocking monoclonal antibodies work by modulating a patient's own immune system...
20.
Harshyne L, Nasca B, Kenyon L, Andrews D, Hooper D
Neuro Oncol
. 2015 Jul;
18(2):206-15.
PMID: 26180083
Background: Glioblastoma (GBM) is an aggressive infiltrative brain tumor with a particularly poor prognosis that is characterized by microvascular proliferation, necrotic tissue, and significant infiltration of M2-like monocytes. Compromised barrier...