Lara Wahlster
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Explore the profile of Lara Wahlster including associated specialties, affiliations and a list of published articles.
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31
Citations
742
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Recent Articles
1.
Fleming T, Antoszewski M, Lambo S, Gundry M, Piussi R, Wahlster L, et al.
bioRxiv
. 2025 Jan;
PMID: 39803492
Acute myeloid leukemias (AMLs) have an overall poor prognosis with many high-risk cases co-opting stem cell gene regulatory programs, yet the mechanisms through which this occurs remain poorly understood. Increased...
2.
Voit R, Liao X, Caulier A, Antoszewski M, Cohen B, Armant M, et al.
Cell Stem Cell
. 2024 Nov;
32(1):38-52.e6.
PMID: 39532107
Gene therapy using hematopoietic stem and progenitor cells is altering the therapeutic landscape for patients with hematologic, immunologic, and metabolic disorders but has not yet been successfully developed for individuals...
3.
Martin-Rufino J, Caulier A, Lee S, Castano N, King E, Joubran S, et al.
bioRxiv
. 2024 Sep;
PMID: 39314298
Most phenotype-associated genetic variants map to non-coding regulatory regions of the human genome. Moreover, variants associated with blood cell phenotypes are enriched in regulatory regions active during hematopoiesis. To systematically...
4.
de Smith A, Wahlster L, Jeon S, Kachuri L, Black S, Langie J, et al.
Cell Genom
. 2024 Mar;
4(4):100526.
PMID: 38537633
Hispanic/Latino children have the highest risk of acute lymphoblastic leukemia (ALL) in the US compared to other racial/ethnic groups, yet the basis of this remains incompletely understood. Through genetic fine-mapping...
5.
Sahoo S, Abdelhamed S, Mochizuki-Kashio M, Wahlster L
Front Oncol
. 2024 Mar;
14:1377974.
PMID: 38434687
No abstract available.
6.
Weng C, Yu F, Yang D, Poeschla M, Liggett L, Jones M, et al.
Nature
. 2024 Jan;
627(8003):389-398.
PMID: 38253266
The human blood system is maintained through the differentiation and massive amplification of a limited number of long-lived haematopoietic stem cells (HSCs). Perturbations to this process underlie diverse diseases, but...
7.
Saffari A, Brechmann B, Boger C, Saber W, Jumo H, Whye D, et al.
Nat Commun
. 2024 Jan;
15(1):584.
PMID: 38233389
Unbiased phenotypic screens in patient-relevant disease models offer the potential to detect therapeutic targets for rare diseases. In this study, we developed a high-throughput screening assay to identify molecules that...
8.
Saffari A, Brechmann B, Boeger C, Saber W, Jumo H, Whye D, et al.
Res Sq
. 2023 Jul;
PMID: 37398196
Unbiased phenotypic screens in patient-relevant disease models offer the potential to detect novel therapeutic targets for rare diseases. In this study, we developed a high-throughput screening assay to identify molecules...
9.
Martin-Rufino J, Castano N, Pang M, Grody E, Joubran S, Caulier A, et al.
Cell
. 2023 May;
186(11):2456-2474.e24.
PMID: 37137305
Systematic evaluation of the impact of genetic variants is critical for the study and treatment of human physiology and disease. While specific mutations can be introduced by genome engineering, we...
10.
Voit R, Tao L, Yu F, Cato L, Cohen B, Fleming T, et al.
Nat Immunol
. 2022 Dec;
24(1):69-83.
PMID: 36522544
The molecular regulation of human hematopoietic stem cell (HSC) maintenance is therapeutically important, but limitations in experimental systems and interspecies variation have constrained our knowledge of this process. Here, we...