Lara C Klett
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Explore the profile of Lara C Klett including associated specialties, affiliations and a list of published articles.
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5
Citations
89
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Recent Articles
1.
Piroeva K, McDonald C, Xanthopoulos C, Fox C, Clarkson C, Mallm J, et al.
Genome Res
. 2023 Sep;
33(10):1649-1661.
PMID: 37699659
The location of nucleosomes in the human genome determines the primary chromatin structure and regulates access to regulatory regions. However, genome-wide information on deregulated nucleosome occupancy and its implications in...
2.
Muckenhuber M, Seufert I, Muller-Ott K, Mallm J, Klett L, Knotz C, et al.
Life Sci Alliance
. 2023 Feb;
6(4).
PMID: 36732019
The antiviral response induced by type I interferon (IFN) via the JAK-STAT signaling cascade activates hundreds of IFN-stimulated genes (ISGs) across human and mouse tissues but varies between cell types....
3.
Hanna B, Llao-Cid L, Iskar M, Roessner P, Klett L, Wong J, et al.
Immunity
. 2021 Dec;
54(12):2825-2841.e10.
PMID: 34879221
T cell exhaustion limits anti-tumor immunity and responses to immunotherapy. Here, we explored the microenvironmental signals regulating T cell exhaustion using a model of chronic lymphocytic leukemia (CLL). Single-cell analyses...
4.
Wierzbinska J, Toth R, Ishaque N, Rippe K, Mallm J, Klett L, et al.
Genome Med
. 2020 Mar;
12(1):29.
PMID: 32188505
Background: In cancer, normal epigenetic patterns are disturbed and contribute to gene expression changes, disease onset, and progression. The cancer epigenome is composed of the epigenetic patterns present in the...
5.
Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks
Mallm J, Iskar M, Ishaque N, Klett L, Kugler S, Muino J, et al.
Mol Syst Biol
. 2019 May;
15(5):e8339.
PMID: 31118277
In chronic lymphocytic leukemia (CLL), a diverse set of genetic mutations is embedded in a deregulated epigenetic landscape that drives cancerogenesis. To elucidate the role of aberrant chromatin features, we...