Lakshmi Kothegala
Overview
Explore the profile of Lakshmi Kothegala including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
63
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0
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Recent Articles
1.
Veerabhadraswamy P, Lata K, Dey S, Belekar P, Kothegala L, Prasad V, et al.
J Extracell Biol
. 2024 Dec;
3(11):e70014.
PMID: 39619685
Multivesicular bodies (MVBs) are vesicles of endosomal origin containing intraluminal vesicles, which upon fusion with plasma membrane, secrete exosomes. They play a significant role in the physiology and pathology of...
2.
Hill T, Gao R, Benrick A, Kothegala L, Rorsman N, Santos C, et al.
Nat Metab
. 2024 Sep;
6(11):2070-2081.
PMID: 39313541
Diabetes mellitus involves both insufficient insulin secretion and dysregulation of glucagon secretion. In healthy people, a fall in plasma glucose stimulates glucagon release and thereby increases counter-regulatory hepatic glucose production....
3.
Gandasi N, Gao R, Kothegala L, Pearce A, Santos C, Acreman S, et al.
Diabetologia
. 2023 Dec;
67(3):528-546.
PMID: 38127123
Aims/hypothesis: Diabetes mellitus is associated with impaired insulin secretion, often aggravated by oversecretion of glucagon. Therapeutic interventions should ideally correct both defects. Glucagon-like peptide 1 (GLP-1) has this capability but...
4.
Kothegala L, Miranda C, Singh M, Krieger J, Gandasi N
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36834860
Recent developments suggest that increased glucagon and decreased somatostatin secretion from the pancreas contribute to hyperglycaemia in type-2 diabetes (T2D) patients. There is a huge need to understand changes in...
5.
Makam A, Biswas A, Kothegala L, Gandasi N
Biomedicines
. 2022 Nov;
10(11).
PMID: 36359215
Type-1-diabetes (T1D) is a multifactorial disorder with a global incidence of about 8.4 million individuals in 2021. It is primarily classified as an autoimmune disorder, where the pancreatic β-cells are...
6.
Gandasi N, Arapi V, Mickael M, Belekar P, Granlund L, Kothegala L, et al.
Int J Mol Sci
. 2021 Jan;
22(3).
PMID: 33503881
SLC38A6 (SNAT6) is the only known member of the SLC38 family that is expressed exclusively in the excitatory neurons of the brain. It has been described as an orphan transporter...
7.
Oduori O, Murao N, Shimomura K, Takahashi H, Zhang Q, Dou H, et al.
J Clin Invest
. 2020 Nov;
130(12):6639-6655.
PMID: 33196462
By restoring glucose-regulated insulin secretion, glucagon-like peptide-1-based (GLP-1-based) therapies are becoming increasingly important in diabetes care. Normally, the incretins GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) jointly maintain normal blood glucose...