Samuel Acreman
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Explore the profile of Samuel Acreman including associated specialties, affiliations and a list of published articles.
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12
Citations
50
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Recent Articles
1.
Hill T, Gao R, Benrick A, Kothegala L, Rorsman N, Santos C, et al.
Nat Metab
. 2024 Sep;
6(11):2070-2081.
PMID: 39313541
Diabetes mellitus involves both insufficient insulin secretion and dysregulation of glucagon secretion. In healthy people, a fall in plasma glucose stimulates glucagon release and thereby increases counter-regulatory hepatic glucose production....
2.
Brandhorst D, Brandhorst H, Acreman S, Johnson P
Bioengineering (Basel)
. 2024 Aug;
11(8).
PMID: 39199786
Throughout the isolation process, human islets are subjected to destruction of the islet basement membrane (BM) and reduced oxygen supply. Reconstruction of the BM represents an option to improve islet...
3.
Acreman S, Ma J, Denwood G, Gao R, Tarasov A, Rorsman P, et al.
iScience
. 2024 Apr;
27(5):109665.
PMID: 38646167
Glucagon is secreted by pancreatic α-cells to counteract hypoglycaemia. How glucose regulates glucagon secretion remains unclear. Here, using mouse islets, we studied the role of transmembrane and endoplasmic reticulum (ER)...
4.
Gandasi N, Gao R, Kothegala L, Pearce A, Santos C, Acreman S, et al.
Diabetologia
. 2023 Dec;
67(3):528-546.
PMID: 38127123
Aims/hypothesis: Diabetes mellitus is associated with impaired insulin secretion, often aggravated by oversecretion of glucagon. Therapeutic interventions should ideally correct both defects. Glucagon-like peptide 1 (GLP-1) has this capability but...
5.
Gao R, Acreman S, Ma J, Abdulkader F, Wendt A, Zhang Q
J Endocrinol
. 2023 May;
258(2).
PMID: 37159865
Glucagon is the principal glucose-elevating hormone that forms the first-line defence against hypoglycaemia. Along with insulin, glucagon also plays a key role in maintaining systemic glucose homeostasis. The cells that...
6.
Brandhorst D, Brandhorst H, Acreman S, Johnson P
Sci Rep
. 2022 Nov;
12(1):19321.
PMID: 36369239
The impact of ischaemia can severely damage procured donor organs for transplantation. The pancreas, and pancreatic islets in particular, is one of the most sensitive tissues towards hypoxia. The present...
7.
McLaughlin K, Acreman S, Nawaz S, Cutteridge J, Clark A, Knudsen J, et al.
Diabet Med
. 2022 Oct;
39(12):e14984.
PMID: 36264270
Background: Tetraspanin-7 (Tspan7) is an islet autoantigen involved in autoimmune type 1 diabetes and known to regulate β-cell L-type Ca channel activity. However, the role of Tspan7 in pancreatic β-cell...
8.
Acreman S, Zhang Q
Chronic Dis Transl Med
. 2022 May;
8(1):7-18.
PMID: 35620162
Glucagon is a potent glucose-elevating hormone that is secreted by pancreatic α-cells. While well-controlled glucagon secretion plays an important role in maintaining systemic glucose homeostasis and preventing hypoglycaemia, it is...
9.
Brandhorst D, Brandhorst H, Layland S, Acreman S, Schenke-Layland K, Johnson P
Acta Biomater
. 2021 Oct;
137:92-102.
PMID: 34653695
Enzymatic digestion of the pancreas during islet isolation is associated with disintegration of the islet basement membrane (IBM) that can cause reduction of functional and morphological islet integrity. Attempts to...
10.
Brandhorst D, Brandhorst H, Acreman S, Abraham A, Johnson P
J Inflamm Res
. 2021 Mar;
14:599-610.
PMID: 33679137
Background: Most islet transplant groups worldwide routinely use the TNFα inhibitor Etanercept in their peri-transplant protocols. Surprisingly, there have been no published dose-response studies on the effects of Etanercept on...