Lakshmi Balagopalan
Overview
Explore the profile of Lakshmi Balagopalan including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
26
Citations
1306
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Balagopalan L, Moreno T, Qin H, Angeles B, Kondo T, Yi J, et al.
Sci Signal
. 2024 Jul;
17(846):eadp8569.
PMID: 39042728
Chimeric antigen receptor (CAR) T cells have been used to successfully treat various blood cancers, but adverse effects have limited their potential. Here, we developed chimeric adaptor proteins (CAPs) and...
2.
Barr V, Piao J, Balagopalan L, McIntire K, Schoenberg F, Samelson L
Microsc Microanal
. 2023 Jul;
29(4):1503-1522.
PMID: 37488826
Activation of the T cell antigen receptor (TCR) is a key step in initiating the adaptive immune response. Single-molecule localization techniques have been used to investigate the arrangement of proteins...
3.
Balagopalan L, Raychaudhuri K, Samelson L
Front Cell Dev Biol
. 2021 Feb;
8:608530.
PMID: 33575254
When T cell receptors (TCRs) engage with stimulatory ligands, one of the first microscopically visible events is the formation of microclusters at the site of T cell activation. Since the...
4.
Bypassing ubiquitination enables LAT recycling to the cell surface and enhanced signaling in T cells
Balagopalan L, Malik H, McIntire K, Garvey J, Nguyen T, Rodriguez-Pena A, et al.
PLoS One
. 2020 Feb;
15(2):e0229036.
PMID: 32084172
LAT molecules defective in ubiquitination have an increased half-life and induce enhanced signaling when expressed in T cells. In this study, we have examined the role of ubiquitination in regulating...
5.
Yi J, Balagopalan L, Nguyen T, McIntire K, Samelson L
Nat Commun
. 2019 Jan;
10(1):277.
PMID: 30655520
Engagement of the T cell receptor (TCR) by stimulatory ligand results in the rapid formation of microclusters at sites of T cell activation. Whereas microclusters have been studied extensively using...
6.
Manna A, Zhao H, Wada J, Balagopalan L, Tagad H, Appella E, et al.
Proc Natl Acad Sci U S A
. 2018 Dec;
115(51):E11914-E11923.
PMID: 30510001
The T cell antigen receptor encounters foreign antigen during the immune response. Receptor engagement leads to activation of specific protein tyrosine kinases, which then phosphorylate multiple enzymes and adapter proteins....
7.
Balagopalan L, Yi J, Nguyen T, McIntire K, Harned A, Narayan K, et al.
Nat Commun
. 2018 May;
9(1):2013.
PMID: 29789604
The relative importance of plasma membrane-localized LAT versus vesicular LAT for microcluster formation and T-cell receptor (TCR) activation is unclear. Here, we show the sequence of events in LAT microcluster...
8.
Palmer D, Guittard G, Franco Z, Crompton J, Eil R, Patel S, et al.
J Exp Med
. 2015 Nov;
212(12):2095-113.
PMID: 26527801
Improving the functional avidity of effector T cells is critical in overcoming inhibitory factors within the tumor microenvironment and eliciting tumor regression. We have found that Cish, a member of...
9.
Balagopalan L, Kortum R, Coussens N, Barr V, Samelson L
J Biol Chem
. 2015 Sep;
290(44):26422-9.
PMID: 26354432
Since the cloning of the critical adapter, LAT (linker for activation of T cells), more than 15 years ago, a combination of multiple scientific approaches and techniques continues to provide...
10.
Guittard G, Kortum R, Balagopalan L, Cuburu N, Nguyen P, Sommers C, et al.
Eur J Immunol
. 2015 May;
45(8):2389-95.
PMID: 25973715
Sos-1 and Sos-2 are ubiquitously expressed Ras-guanine exchange factors involved in Erk-MAP kinase pathway activation. Using mice lacking genes encoding Sos-1 and Sos-2, we evaluated the role of these proteins...