Lai-Xi Wang
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Explore the profile of Lai-Xi Wang including associated specialties, affiliations and a list of published articles.
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181
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Recent Articles
1.
Sotomayor B, Donahue T, Mahajan S, Taw M, Hulbert S, Bidstrup E, et al.
bioRxiv
. 2024 Nov;
PMID: 39574765
Human immunoglobulin G (IgG) antibodies are one of the most important classes of biotherapeutic agents and undergo glycosylation at the conserved N297 site in the C2 domain, which is critical...
2.
Iqbal M, Feng C, Zong G, Wang L, Vasta G
Glycobiology
. 2024 Nov;
35(1).
PMID: 39569730
Galectins are β-galactosyl-binding lectins with key roles in early development, immune regulation, and infectious disease. Influenza A virus (IAV) infects the airway epithelia, and in severe cases may lead to...
3.
Huang K, Bashian E, Zong G, Nycholat C, McBride R, Gomozkova M, et al.
JACS Au
. 2024 Aug;
4(8):2966-2978.
PMID: 39211606
Sulfated -glycans are present in many glycoproteins, which are implicated in playing important roles in biological recognition processes. Here, we report the systematic chemoenzymatic synthesis of a library of sulfated...
4.
Yang Q, Chen H, Ou C, Zheng Z, Zhang X, Liu Y, et al.
Antibodies (Basel)
. 2023 Nov;
12(4).
PMID: 37987249
Fc-glycosite-specific antibody-drug conjugation represents a promising direction for the preparation of site-specific antibody-drug conjugates (ADCs). In the present research, we conducted a systemic evaluation of two endoglycosidase-catalyzed chemoenzymatic glycoengineering technologies...
5.
Campos D, Girgis M, Yang Q, Zong G, Goldman R, Wang L, et al.
Anal Chem
. 2023 Jun;
95(27):10145-10148.
PMID: 37382290
Mass spectrometry (MS) can unlock crucial insights into the intricate world of glycosylation analysis. Despite its immense potential, the qualitative and quantitative analysis of isobaric glycopeptide structures remains one of...
6.
Donahue T, Ou C, Yang Q, Flinko R, Zhang X, Zong G, et al.
ACS Chem Biol
. 2023 Jun;
18(7):1611-1623.
PMID: 37368876
Targeted degradation using cell-specific lysosome targeting receptors is emerging as a new therapeutic strategy for the elimination of disease-associated proteins. The liver-specific human asialoglycoprotein receptor (ASGPR) is a particularly attractive...
7.
Campos D, Girgis M, Yang Q, Zong G, Goldman R, Wang L, et al.
bioRxiv
. 2023 Jun;
PMID: 37292769
Graphical Abstract:
8.
Trastoy B, Du J, Cifuente J, Rudolph L, Garcia-Alija M, Klontz E, et al.
Nat Commun
. 2023 Mar;
14(1):1705.
PMID: 36973249
Bacterial pathogens have evolved intricate mechanisms to evade the human immune system, including the production of immunomodulatory enzymes. Streptococcus pyogenes serotypes secrete two multi-modular endo-β-N-acetylglucosaminidases, EndoS and EndoS2, that specifically...
9.
Chen X, Gula H, Pius T, Ou C, Gomozkova M, Wang L, et al.
Proc Natl Acad Sci U S A
. 2023 Mar;
120(14):e2220765120.
PMID: 36972444
Antibodies bind target molecules with exquisite specificity. The removal of these targets is mediated by the effector functions of antibodies. We reported earlier that the monoclonal antibody (mAb) 3F6 promotes...
10.
Sanda M, Yang Q, Zong G, Chen H, Zheng Z, Dhani H, et al.
J Proteome Res
. 2023 Feb;
22(4):1138-1147.
PMID: 36763792
Targeted quantification of proteins is a standard methodology with broad utility, but targeted quantification of glycoproteins has not reached its full potential. The lack of optimized workflows and isotopically labeled...