Laetitia K Linares
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Explore the profile of Laetitia K Linares including associated specialties, affiliations and a list of published articles.
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30
Citations
1479
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Recent Articles
1.
Manteaux G, Amsel A, Riquier-Morcant B, Prieto Romero J, Gayte L, Fourneaux B, et al.
Nat Commun
. 2024 Sep;
15(1):7940.
PMID: 39266552
Dedifferentiated and Well-differentiated liposarcoma are characterized by a systematic amplification of the Murine Double Minute 2 (MDM2) oncogene. We demonstrate that p53-independent metabolic functions of chromatin-bound MDM2 are exacerbated in...
2.
Gruel N, Quignot C, Lesage L, El Zein S, Bonvalot S, Tzanis D, et al.
Nat Commun
. 2024 Sep;
15(1):7941.
PMID: 39266532
Dedifferentiated liposarcoma (DDLPS) is the most frequent high-grade soft tissue sarcoma subtype. It is characterized by a component of undifferentiated tumor cells coexisting with a component of well-differentiated adipocytic tumor...
3.
Riscal R, Riquier-Morcant B, Gadea G, Linares L
Methods Mol Biol
. 2024 Feb;
2740:155-168.
PMID: 38393475
Cell cycle is an ordered sequence of events that occur in a cell preparing for cell division . The cell cycle is a four-stage process in which the cell increases...
4.
Jacquier V, Gitenay D, Fritsch S, Bonnet S, Gyorffy B, Jalaguier S, et al.
Cell Mol Life Sci
. 2022 May;
79(5):270.
PMID: 35501580
Glycolysis is essential to support cancer cell proliferation, even in the presence of oxygen. The transcriptional co-regulator RIP140 represses the activity of transcription factors that drive cell proliferation and metabolism...
5.
Lacroix M, Linares L, Rueda-Rincon N, Bloch K, Di Michele M, De Blasio C, et al.
Nat Commun
. 2021 Dec;
12(1):7037.
PMID: 34857760
Growing evidence supports the importance of the p53 tumor suppressor in metabolism but the mechanisms underlying p53-mediated control of metabolism remain poorly understood. Here, we identify the multifunctional E4F1 protein...
6.
Stuani L, Sabatier M, Saland E, Cognet G, Poupin N, Bosc C, et al.
J Exp Med
. 2021 Mar;
218(5).
PMID: 33760042
Mutations in IDH induce epigenetic and transcriptional reprogramming, differentiation bias, and susceptibility to mitochondrial inhibitors in cancer cells. Here, we first show that cell lines, PDXs, and patients with acute...
7.
Lahalle A, Lacroix M, De Blasio C, Cisse M, Linares L, Le Cam L
Cancers (Basel)
. 2021 Jan;
13(1).
PMID: 33406607
The p53 pathway is functionally inactivated in most, if not all, human cancers. The p53 protein is a central effector of numerous stress-related molecular cascades. p53 controls a safeguard mechanism...
8.
Cisse M, Pyrdziak S, Firmin N, Gayte L, Heuillet M, Bellvert F, et al.
Sci Transl Med
. 2020 Jun;
12(547).
PMID: 32522803
Well-differentiated and dedifferentiated liposarcomas (LPSs) are characterized by a systematic amplification of the oncogene, which encodes a key negative regulator of the p53 pathway. The molecular mechanisms underlying MDM2 overexpression...
9.
Heuillet M, Millard P, Cisse M, Linares L, Letisse F, Manie S, et al.
Anal Chem
. 2020 Mar;
92(8):5890-5896.
PMID: 32212637
Studies of the topology, functioning, and regulation of metabolic systems are based on two main types of information that can be measured by mass spectrometry: the (absolute or relative) concentration...
10.
Champagne J, Linares L, Maurel B, Zampieri A, Moreno M, Fuentes I, et al.
Oncogene
. 2019 Sep;
39(4):935-945.
PMID: 31558799
RNA interference offers therapeutic opportunities for the clinical targeting of otherwise undruggable oncogenes. However RNAi can have off-target effects that considerably increase treatment risks. To manage these side effects and...